Different Spectra of Stationary-Phase Mutations in Early-Arising versus Late-Arising Mutants of Pseudomonas putida: Involvement of the DNA Repair Enzyme MutY …

S Saumaa, A Tover, L Kasak, M Kivisaar - Journal of bacteriology, 2002 - Am Soc Microbiol
Stationary-phase mutations occur in populations of stressed, nongrowing, and slowly
growing cells and allow mutant bacteria to overcome growth barriers. Mutational processes …

Promoter-creating mutations in Pseudomonas putida: A model system for the study of mutation in starving bacteria

L Kasak, R HOrak, M Kivisaar - Proceedings of the National …, 1997 - National Acad Sciences
A novel experimental system to study mutation in starving bacteria was designed, relying on
the activation of a promoterless phenol degradation operon of Pseudomonas putida. The …

Mechanisms of stationary-phase mutagenesis in bacteria: mutational processes in pseudomonads

M Kivisaar - FEMS microbiology letters, 2010 - academic.oup.com
In a growth-restricting environment, mutants arise that are able to take over bacterial
populations by a process known as adaptive mutation or stationary-phase mutation. This …

Involvement of DNA mismatch repair in stationary-phase mutagenesis during prolonged starvation of Pseudomonas putida

S Saumaa, K Tarassova, M Tark, A Tover, R Tegova… - DNA repair, 2006 - Elsevier
One of the popular ideas is that decline in methyl-directed mismatch repair (MMR) in carbon-
starved bacteria might facilitate occurrence of stationary-phase mutations. We compared the …

Mutation Frequency and Spectrum of Mutations Vary at Different Chromosomal Positions of Pseudomonas putida

T Juurik, H Ilves, R Teras, T Ilmjärv, K Tavita, K Ukkivi… - PLoS …, 2012 - journals.plos.org
It is still an open question whether mutation rate can vary across the bacterial chromosome.
In this study, the occurrence of mutations within the same mutational target sequences at …

Elevated Mutation Frequency in Surviving Populations of Carbon-Starved rpoS-Deficient Pseudomonas putida Is Caused by Reduced Expression of Superoxide …

K Tarassova, R Tegova, A Tover, R Teras… - Journal of …, 2009 - Am Soc Microbiol
RpoS is a bacterial sigma factor of RNA polymerase which is involved in the expression of a
large number of genes to facilitate survival under starvation conditions and other stresses …

Oxidative DNA Damage Defense Systems in Avoidance of Stationary-Phase Mutagenesis in Pseudomonas putida

S Saumaa, A Tover, M Tark, R Tegova… - Journal of …, 2007 - Am Soc Microbiol
Oxidative damage of DNA is a source of mutation in living cells. Although all organisms have
evolved mechanisms of defense against oxidative damage, little is known about these …

Adaptive Mutagenesis at ebgR Is Regulated by PhoPQ

BG Hall - Journal of bacteriology, 1998 - Am Soc Microbiol
Adaptive mutations are mutations that occur in nondividing or very slowly dividing microbial
cells during prolonged nonlethal selection and that are specific to the challenge of the …

The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutants

A Oliver, F Baquero, J Blázquez - Molecular microbiology, 2002 - Wiley Online Library
We have recently described the presence of a high proportion of Pseudomonas aeruginosa
isolates (20%) with an increased mutation frequency (mutators) in the lungs of cystic fibrosis …

Impact of mutS Inactivation on Foreign DNA Acquisition by Natural Transformation in Pseudomonas stutzeri

P Meier, W Wackernagel - Journal of bacteriology, 2005 - Am Soc Microbiol
In prokaryotic mismatch repair the MutS protein and its homologs recognize the mismatches.
The mutS gene of naturally transformable Pseudomonas stutzeri ATCC 17587 (genomovar …