Abstract Purpose Non-European populations are under-represented in genetics studies,
hindering clinical implementation of breast cancer polygenic risk scores (PRSs). We aimed …

The promise of personalized genomic medicine is that knowledge of a person's gene
sequences and activity will facilitate more appropriate medical interventions, particularly …

Over the past decade, substantial progress has been made in the discovery of alleles
contributing to the risk of coronary artery disease. In addition to providing causal insights into …

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because
it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for …

Background Genome-wide association studies have identified common genetic risk variants
in many loci associated with multiple cancers. We sought to systematically evaluate the …

Genomewide Association Studies — Illuminating Biologic Pathways | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …

Background It is proposed that, through restriction to individuals delineated as high risk,
polygenic risk scores (PRSs) might enable more efficient targeting of existing cancer …

Importance Multiple polygenic risk scores (PRSs) for breast cancer have been developed
from large research consortia; however, their generalizability to diverse clinical settings is …

Polygenic risk scores (PRS) for prostate cancer incidence have been proposed to optimize
prostate cancer screening. Prediction of lethal prostate cancer is key to any stratified …

Purpose: Single genetic variants in multifactorial disorders typically have small effects, so
major increases in disease risk are expected only from the simultaneous exposure to …