Liver transplant is the only curative treatment option for patients with end-stage liver failure,
however there are few donor livers available for transplant. Tissue engineering of a human …

We have developed a hydrogel-based cell cultivation platform for forming 3D restiform
hepatic micro-organoids consisting of primary rat hepatocytes and feeder cells (Swiss 3T3 …

Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor
prognosis. It is thought to originate from cholangiocytes, which are the component cells of …

Tissue engineering requires growth factors, cells and a scaffold to permit effective tissue
regeneration. This study focused on the development of a scaffold for liver tissue …

BACKGROUND & AIMS: Intrahepatic drug delivery from implantable scaffolds is being
developed as a strategy to modulate growth and enhance regeneration at the time of liver …

Adult tissue stem cells can form self-organizing 3D organoids in vitro. Organoids resemble
small units of their organ of origin and have great potential for tissue engineering, as well as …

The rat is an important model for liver regeneration. However, there is no in vitro culture
system that can capture the massive proliferation that can be observed after partial …

Background Acute liver failure (ALF) is a life-threatening disease with a high mortality rate.
However, there are limited treatments or devices available for ALF therapy. Here, we aimed …

Human livers have maturational lineages of cells within liver acini, beginning periportally in
stem cell niches, the canals of Hering, and ending in polyploid hepatocytes pericentrally and …

Tissue engineering is a promising approach to developing hepatic tissue suitable for the
functional replacement of a failing liver. The aim of the present study was to investigate …