A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic
pathway of cellular suicide that appears to be common to all multicellular animals. A related …

The Bcl‐2 family of proteins regulate apoptosis, some antagonizing cell death and others
facilitating it. It has recently been demonstrated that Bcl‐2 not only inhibits apoptosis but also …

The BCL-2 gene was identified at the chromosomal breakpoint of t (14; 18)-bearing human
follicular B cell lymphomas. BCL-2 proved to block programmed cell death rather than …

The genetic control of tumorigenesis has been greatly advanced by the discovery of
oncogenes. A central dogma holds that oncogenes induce an overt proliferation providing …

The oncogene product Bcl-2 effectively spares cells from programmed cell death
(apoptosis). The molecular mechanism underlying this death-protective activity has …

The Bcl-2 protein inhibits apoptosis induced by a variety of signals, in a range of cell types
and in diverse organisms, and it is implicated in both normal development and oncogenesis …

Bcl-2 and Bax are members of a family of cytoplasmic proteins that regulate apoptosis. The
two proteins have highly similar amino acid sequences but are functionally opposed: Bcl-2 …

HE terms programmed cell death (PCD) 1 and apoptosis are often used interchangeably to
describe a mechanism of cellular demise that is believed to play an important role in a wide …

Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the
mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We …

The last 30 years of studying BCL2 have brought cell death research into the molecular era,
and revealed its relevance to human pathophysiology. Most, if not all metazoans use an …