Generation of a robust immunological memory response is essential for protection on
subsequent encounters with the same pathogen. The magnitude and quality of the memory …

Strength of inflammatory stimuli during the early expansion phase plays a crucial role in the
effector versus memory cell fate decision of CD8+ T cells. But it is not known how early …

The development of T cell memory from naive precursors is influenced by molecular cues
received during T cell activation and differentiation. In this study, we describe a novel role for …

It has been proposed that expression of the chemokine receptor CCR7 represents a defining
factor for nonpolarized central (CCR7+) and polarized effector memory (CCR7−) T cells. In …

Because T cells act primarily through short-distance interactions, homing receptors can
identify colocalizing cells that serve common functions. Expression patterns for multiple …

We previously reported that central–memory T cells (TCM cells), which express lymph node
homing receptors CCR7 and CD62L, are largely devoid of effector functions but acquire …

Memory T cells are central to orchestrating antigen-specific recall responses in vivo.
Compared to naïve T cells, memory T cells respond more quickly to cognate peptide: MHC …

Because the chemokine receptor CCR5 is expressed on Th1 CD4+ cells, it is important to
investigate the expression and function of this receptor on other T cells involved in Th1 …

CC receptor 7 (CCR7) is important to allow T cells and dendritic cells to migrate toward
CCL19-and CCL21-producing cells in the T-cell zone of the spleen and lymph nodes. The …

After an infection, the immune system generates long-lived memory lymphocytes whose
increased frequency and altered state of differentiation enhance host defense against …