Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues

P Kovvuru, PE Mancilla, AB Shirode, TM Murray… - …, 2015 - Taylor & Francis
Silver nanoparticles (AgNPs) are widely used in consumer and medical products. However,
most AgNP toxicity data are based on in vitro studies. Only a few studies were performed in …

Particle coatings but not silver ions mediate genotoxicity of ingested silver nanoparticles in a mouse model

S Nallanthighal, C Chan, DJ Bharali, SA Mousa… - NanoImpact, 2017 - Elsevier
Incorporation of silver nanoparticles (AgNPs) in toothpaste, food containers, dietary
supplements and other consumer products can result in oral exposure to AgNPs and/or …

Comparative genotoxicity of silver nanoparticles in human liver HepG2 and lung epithelial A549 cells

J Wang, B Che, LW Zhang, G Dong… - Journal of Applied …, 2017 - Wiley Online Library
With the rapid expanding of human exposure to silver nanoparticles (AgNPs), genotoxicity
screening of nanosilver is necessary to ensure consumer safety. Here, we assessed one key …

Cytotoxicity and genotoxicity assessment of silver nanoparticles in mouse

Y Li, JA Bhalli, W Ding, J Yan, MG Pearce… - …, 2014 - Taylor & Francis
Silver nanoparticles (AgNPs) are among the most commercially used nanomaterials and
their toxicity and genotoxicity are controversial. Although many in vitro studies have been …

Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells

PV AshaRani, S Sethu, HK Lim, G Balaji… - Genome integrity, 2012 - Springer
Background Investigating the cellular and molecular signatures in eukaryotic cells following
exposure to nanoparticles will further our understanding on the mechanisms mediating …

Toxicity and chemical transformation of silver nanoparticles in A549 lung cells: Dose-rate-dependent genotoxic impact

L Bobyk, A Tarantini, D Beal, G Veronesi… - Environmental …, 2021 - pubs.rsc.org
Silver nanoparticles (Ag-NPs) are widely used as biocides, leading to contamination of the
environment and possible adverse effects on humans. Recent studies revealed that the …

[PDF][PDF] Manufactured silver nanoparticles of different sizes induced DNA strand breaks and oxidative DNA damage in hepatoma and leukaemia cells and in dermal …

A Ávalos, AI Haza, P Morales - Folia Biologica, 2015 - fb.cuni.cz
Many classes of silver nanoparticles (AgNPs) have been synthesized and widely applied,
but no conclusive information on their potential cytotoxicity and genotoxicity mechanisms is …

Genotoxic effects of silver nanoparticles with/without coating in human liver HepG2 cells and in mice

X Wang, T Li, X Su, J Li, W Li, J Gan… - Journal of Applied …, 2019 - Wiley Online Library
With the rapid expansion of human exposure to silver nanoparticles (AgNPs), the
genotoxicity screening is critical to the biosafety evaluation of nanosilver. This study …

Differential genotoxicity mechanisms of silver nanoparticles and silver ions

Y Li, T Qin, T Ingle, J Yan, W He, JJ Yin, T Chen - Archives of toxicology, 2017 - Springer
In spite of many reports on the toxicity of silver nanoparticles (AgNPs), the mechanisms
underlying the toxicity are far from clear. A key question is whether the observed toxicity …

In vivo DNA damaging and apoptotic potential of silver nanoparticles in Swiss albino mice

MA Al Gurabi, D Ali, S Alkahtani… - OncoTargets and therapy, 2015 - Taylor & Francis
Nanoparticles can potentially cause adverse effects on organs, tissue, cell levels, and
protein levels because of their physicochemical properties. Silver nanoparticles (AgNPs) are …