[HTML][HTML] The p38 MAPK stress pathway as a tumor suppressor or more?

M Loesch, G Chen - Frontiers in bioscience: a journal and virtual …, 2008 - ncbi.nlm.nih.gov
Abstract p38 mitogen-activated protein kinases (p38 MAPKs) are a group of serine/threonine
protein kinases that together with ERK (extracellular signal-regulated kinases) and JNK (c …

p38MAPK: stress responses from molecular mechanisms to therapeutics

LR Coulthard, DE White, DL Jones… - Trends in molecular …, 2009 - cell.com
The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

p38 MAP kinase's emerging role as a tumor suppressor

DV Bulavin, AJ Fornace - Advances in cancer research, 2004 - books.google.com
The p38 proteins are an evolutionally conserved family of mitogen-activated protein kinases
(MAPK). Recent studies have led to progress in our understanding the roles of p38 MAPK in …

MAPK signaling in inflammation-associated cancer development

P Huang, J Han, L Hui - Protein & cell, 2010 - Springer
Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine
kinases, which are highly conserved in protein structures from unicellular eukaryotic …

[HTML][HTML] p38α antagonizes p38γ activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response

X Qi, NM Pohl, M Loesch, S Hou, R Li, JZ Qin… - Journal of Biological …, 2007 - ASBMB
p38 MAPK family consists of four isoform proteins (α, β, γ, and δ) that are activated by the
same stimuli, but the information about how these proteins act together to yield a biological …

Role of p38 MAP kinase signal transduction in solid tumors

HK Koul, M Pal, S Koul - Genes & cancer, 2013 - journals.sagepub.com
Mitogen-activated protein kinases (MAPKs) mediate a wide variety of cellular behaviors in
response to extracellular stimuli. One of the main subgroups, the p38 MAP kinases, has …

Signal integration by JNK and p38 MAPK pathways in cancer development

EF Wagner, ÁR Nebreda - Nature Reviews Cancer, 2009 - nature.com
Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family
members function in a cell context-specific and cell type-specific manner to integrate signals …

[HTML][HTML] Activation and signaling of the p38 MAP kinase pathway

T Zarubin, J Han - Cell research, 2005 - nature.com
The family members of the mitogen-activated protein (MAP) kinases mediate a wide variety
of cellular behaviors in response to extracellular stimuli. One of the four main sub-groups …

[HTML][HTML] Non-classical p38 map kinase functions: cell cycle checkpoints and survival

TM Thornton, M Rincon - International journal of biological …, 2009 - ncbi.nlm.nih.gov
The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …

Compromised MAPK signaling in human diseases: an update

EK Kim, EJ Choi - Archives of toxicology, 2015 - Springer
The mitogen-activated protein kinases (MAPKs) in mammals include c-Jun NH 2-terminal
kinase (JNK), p38 MAPK, and extracellular signal-regulated kinase (ERK). These enzymes …