Background The appropriateness of direct oral anticoagulant (DOAC) dosing has been the
issue in the real-world setting, and inappropriately lower DOAC dose may not be as effective …

Background: Direct oral anticoagulants (DOACs) are preferred for stroke prevention in atrial
fibrillation (AF). However, off-label doses have been associated with increased risk of …

Essentials• Direct oral anticoagulants (DOACs) do not require laboratory monitoring
currently.• DOAC specific measurements were performed at trough in patients with atrial …

Abstract Background Direct oral anticoagulants (DOACs) reduce the risk of stroke and
systemic embolism in patients with nonvalvular atrial fibrillation but may result in serious …

The disease burden of AF is greater in Asia-Pacific than other areas of the world. Direct oral
anticoagulants (DOACs) have emerged as effective alternatives to vitamin K antagonists …

Background: Current guidelines recommend using direct oral anticoagulants (DOACs) over
warfarin in patients with atrial fibrillation (AF), but head-to-head trial data do not exist to …

Background: Evidence is conflicting as to the efficacy of direct oral anticoagulation (DOAC)
and vitamin K antagonist (VKA) for prevention of myocardial infarction (MI). Objectives: This …

Objective: To conduct a systematic literature review (SLR) and network meta-analysis (NMA)
of real-world studies comparing major bleeding risk among patients with non-valvular atrial …

Aims There are conflicting signals in the literature about comparative safety and
effectiveness of direct oral anticoagulants (DOACs) for nonvalvular atrial fibrillation (NVAF) …

Objective: Oral anticoagulation (OAC) prescribed to AF patients for the prevention of
cardioembolic complications likely has the added benefit of preventing venous …