Targeting ERK1/2 protein-serine/threonine kinases in human cancers
R Roskoski Jr - Pharmacological research, 2019 - Elsevier
ERK1 and ERK2 are key protein kinases that contribute to the Ras-Raf-MEK-ERK MAP
kinase signalling module. This pathway participates in the control of numerous processes …
kinase signalling module. This pathway participates in the control of numerous processes …
Targeting aberrant RAS/RAF/MEK/ERK signaling for cancer therapy
U Degirmenci, M Wang, J Hu - Cells, 2020 - mdpi.com
The RAS/RAF/MEK/ERK (MAPK) signaling cascade is essential for cell inter-and intra-
cellular communication, which regulates fundamental cell functions such as growth, survival …
cellular communication, which regulates fundamental cell functions such as growth, survival …
MAP kinase signaling and inhibition in melanoma
RJ Sullivan, K Flaherty - Oncogene, 2013 - nature.com
The mitogen-activated protein kinase (MAPK) pathway is critical to oncogenic signaling in
the majority of patients with malignant melanoma. Driver mutations in both NRAS and BRAF …
the majority of patients with malignant melanoma. Driver mutations in both NRAS and BRAF …
Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF–MEK–ERK pathway in cancer
GL Johnson, TJ Stuhlmiller, SP Angus… - Clinical Cancer …, 2014 - AACR
The central role of the BRAF–MEK–ERK pathway in controlling cell fate has made this
pathway a primary target for deregulated activation in cancer. BRaf is activated by Ras …
pathway a primary target for deregulated activation in cancer. BRaf is activated by Ras …
Hyperactivation of MAPK signaling is deleterious to RAS/RAF-mutant melanoma
GP Leung, T Feng, FD Sigoillot, FC Geyer… - Molecular Cancer …, 2019 - AACR
The most frequent genetic alterations in melanoma are gain-of-function (GOF) mutations in
BRAF, which result in RAF–MEK–ERK signaling pathway addiction. Despite therapeutic …
BRAF, which result in RAF–MEK–ERK signaling pathway addiction. Despite therapeutic …
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches
A De Luca, MR Maiello, A D'Alessio… - Expert opinion on …, 2012 - Taylor & Francis
Introduction: The RAS/RAF/MAP kinase–ERK kinase (MEK)/extracellular-signal-regulated
kinase (ERK)(MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR)(PI3K) …
kinase (ERK)(MAPK) and the PI3K/AKT/mammalian target of rapamycin (mTOR)(PI3K) …
[HTML][HTML] The mitogen-activated protein kinase pathway in melanoma part I–activation and primary resistance mechanisms to BRAF inhibition
Mitogen-activated protein kinase (MAPK) pathway has an important role in normal cells and
can be activated under physiological conditions. MAPK pathway activation is a fundamental …
can be activated under physiological conditions. MAPK pathway activation is a fundamental …
Targeting MAPK signaling in cancer: mechanisms of drug resistance and sensitivity
Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
pathways that regulate all aspects of life and are frequently altered in disease. Here, we …
The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction
The RAF–MEK–ERK mitogen-activated protein kinase (MAPK) cascade is aberrantly
activated in a diverse set of human cancers and the RASopathy group of genetic …
activated in a diverse set of human cancers and the RASopathy group of genetic …
Targeting alterations in the RAF–MEK pathway
R Yaeger, RB Corcoran - Cancer discovery, 2019 - AACR
The MAPK pathway is one of the most commonly mutated oncogenic pathways in cancer.
Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in …
Although RAS mutations are the most frequent MAPK alterations, less frequent alterations in …