Serotonergic dysfunction is implicated in Alzheimer's disease (AD). In addition, reductions in
brain of both monoamine synthesis and release have been reported. Serotonin 1B receptors …

Serotonin (5-HT) plays a central role in the integrity of different brain functions. The 5-HT
homeostasis is regulated by many factors, including serotonin transporter (SERT) …

Intrahippocampal injections of aggregated amyloid-β (Aβ) 1-42 in rats result in memory
impairment and in reduction of hippocampal 5-HT 2A receptor levels. In order to investigate …

Background: Although mood and sleep disturbances are nearly universal among patients
with Alzheimer's disease (AD), brain structures involved in non-cognitive processing remain …

Background Discrepant and often contradictory results have accumulated regarding the
antidepressant and pro-cognitive effects of serotonin transporter (SERT) antagonists in …

The etiology of late-onset Alzheimer's disease (AD) and idiopathic Parkinson's disease (PD)
is not known. In both disorders there is an extensive degeneration of serotonergic neurons …

Background It has been hypothesized that alterations of the serotonergic system contribute
to neuropsychiatric symptoms in Alzheimer disease (AD). Cellular expressions of the two …

Genetic variants of the serotonergic neurotransmitter system are potential contributing
factors in the pathological processes underlying Alzheimer's disease (AD). We examined …

Background: A decline of brain serotonin (5-HT) is held responsible for the changes in mood
that can be observed in Alzheimer's disease (AD). However, 5-HT'ergic signaling is also …

Background: Neuropathological and neuroimaging studies have demonstrated
degeneration of the serotonin system in Alzheimer's disease (AD). Neuroimaging studies …