Because it allows direct mapping of synaptic activity during behavior in the normal subject,
functional neuroimaging with the activation paradigm, especially positron emission …

Older adults often show bilateral brain activation, compared to unilateral activation in
younger adults, when performing tasks in domains of age-associated cognitive impairment …

Cross-sectional neuroimaging studies suggest that hippocampal and prefrontal cortex
functions underlie individual differences in memory ability in older individuals, but it is …

Memory is one of the cognitive functions that deteriorate most with age. The types of memory
most affected by aging are working memory, the short-term memory maintenance and …

Reduced moment-to-moment blood oxygen level-dependent (BOLD) signal variability has
been consistently linked to advanced age and poorer cognitive performance, showing …

Our understanding of the ways in which changes in specific neural systems mediate adult
age differences in memory is rapidly increasing, due in no small part to the advent of …

The concept of reserve arose from the mismatch between the extent of brain changes or
pathology and the clinical manifestations of these brain changes. The cognitive reserve …

Since the time of Aristotle it has been thought that memories can be divided into two basic
types; conscious recollections and familiarity‐based judgments. Neuropsychological studies …

Normal aging is often accompanied by impairments in forming new memories, and studies
of aging rodents have revealed structural and functional changes to the hippocampus that …

Surprisingly little is known about the neural correlates of remembering real life events in the
context of normal aging. We therefore asked young and older adults to retrieve real life …