Women and female rodents are more responsive to the subjective effects of psychostimulant
drugs of abuse compared to males. A growing body of literature supports a role for estradiol …

Progesterone replacement attenuates the intensity of cocaine-induced conditioned place
preference (CPP) behaviors in female rats. The present study aimed to expand that finding …

Introduction: The present study aimed to determine if, as occurs in female rats, progesterone
attenuates cocaine-induced reward and psychomotor responses in male rats. Methods: The …

There is accumulating evidence that suggests there are sex differences in behavioral and
subjective responses to cocaine. However, it is not known whether differences in cocaine …

Several recent reports have demonstrated sex differences in the behavioral and
neurochemical response to cocaine. However, it is not clear whether differences exist in …

Rationale Systemic estradiol (E2) increases the behavioral and neural response to cocaine.
Where in the brain E2 acts to modulate cocaine response is not entirely clear. Evidence …

Estradiol modulates the rewarding and reinforcing properties of cocaine in females,
including an increase in selection of cocaine over alternative reinforcers. However, the …

Background Females are more vulnerable to developing cocaine addiction compared with
males, a phenomenon that may be regulated by the steroid hormone 17β-estradiol. 17β …

The aim of the present study was to determine if pre-exposure to high doses of cocaine can
subsequently alter the rewarding effects of this drug. Adult male mice received a …

A consistent finding in drug abuse research is that males and females show differences in
their response to drugs of abuse. In women, increased plasma estradiol is associated with …