Rationale Previous studies have shown that female rats exhibit enhanced cocaine-seeking
across several phases of the addiction cycle when compared to males. Drug-seeking in …

Clinical research suggests that gender differences exist in cocaine dependence. Similarly,
preclinical studies have shown that female rats exhibit higher response rates during cocaine …

Human and animal laboratory studies show that females and males respond differently to
drugs and that drug administration during adolescence leads to different behavioral effects …

Evidence suggests the existence of genetic differences in cocaine sensitization in male rats.
The present study was undertaken to investigate cocaine sensitization in female rats of …

Ovarian hormones play a role in the use of drugs of abuse in women. In female rats estradiol
has been shown to enhance acquisition of cocaine self-administration and behavioral …

Cocaine self-administration in rodents has been used widely as a preclinical model of
cocaine use in humans. In laboratory animals, estradiol enhances behavioral sensitization …

Estradiol benzoate (EB) facilitates the acquisition and reinstatement of cocaine-seeking
behavior when administered to ovariectomized (OVX) rats. In contrast, progesterone (P) …

Both humans and experimental animals demonstrate gender differences in response to
cocaine. However, the mechanisms underlying these differences remain unclear. The …

It is well established that there are estrous cycle differences in cocaine-induced behavioral
activity, implicating fluctuations in levels of estrogen and progesterone throughout the cycle …

Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and
may be influenced by their sex hormones. We compared the modulatory effects of …