Objective (s): Growing evidence demonstrates that L-arginine/NO/cGMP/K ATP channel
pathway has a modulatory role in pain perception. Previous studies have shown that …

Protocatechuic acid (PCA) is a widely distributed natural bioactive phenolic acid. The
various pharmacological activities such as antioxidant, antidiabetic and anti-inflammatory …

Objectives The main purpose of this study was to assess the role of l-arginine/SNAP/NO/
cGMP/KATP channel pathway in analgesic effects of α-terpineol in mice. Methods Male …

The perception of pain caused by inflammation serves as a warning sign to avoid further
injury. The generation and transmission of pain impulses involves various pathways and …

The present study was conducted to evaluate the local antinociceptive actions of EA and the
possible involvement of l-arginine/NO/cGMP/K ATP channel pathway in this effect using …

Metoclopramide, a prokinetic drug, has been documented to produce antinociceptive
response in animal models through opioid pathways. Morphine has been shown to act …

Background It has been reported that curcumin, the main active compound of Curcuma
longa, also known as turmeric, exhibits antinociceptive properties. The aim of this study was …

Background Recent studies pointed up that curcumin produces an anti-nociceptive effect in
inflammatory and neuropathic pain. However, the possible mechanisms of action that …

Substances derived from plants play an important role in the development of new analgesic
drugs, among them, triterpenoids. The connection between the participation of L …

Background and purpose: Cnicus benedictus, a medicinal herb, traditionally had been used
for the treatment of stomachache pain. In this study, the possible efficacy of Cnicus …