For the past 40years or so, oxidative stress has been increasingly recognized as a
contributing factor in aging and in various forms of pathophysiology generally associated …

Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

The brain is very sensitive to changes in redox status; thus maintaining redox homeostasis
in the brain is critical for the prevention of accumulating oxidative damage. Aging is the …

Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a key transcription factor that plays a
central role in cellular defense against oxidative and electrophilic insults by timely induction …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Free radicals, reactive oxygen/nitrogen species (ROS/RNS), hydrogen sulphide, and
hydrogen peroxide play an important role in both intracellular and intercellular signaling; …

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2; encoded in humans by the NFE2L2 gene) is
a transcription factor that regulates the gene expression of a wide variety of cytoprotective …

The coordinating role of nuclear factor erythroid-2-related factor 2 (Nrf2) in cellular function
is undeniable. Evidence indicates that this transcription factor exerts massive regulatory …

NRF2, a transcription factor that has been deemed the master regulator of cellular redox
homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat …

The innate immune system, including phagocytic cells, is the first line of defense against
pathogens. During infection by microorganisms such as viruses, bacteria, or parasites …