Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …

Nuclear factor, erythroid 2 related factor 2 (Nrf2) belongs to the Cap'n'collar/basic region
leucine zipper (CNC-bZIP) transcription factor family, and is activated by diverse oxidants …

Nrf2 is a key transcription factor in the cellular response to oxidative stress. In this study we
identify two phosphorylated forms of endogenous human Nrf2 after chemically induced …

The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most
important oxidative stress regulator in the human body. Once Nrf2 regulates the expression …

The capacity of cells to maintain homeostasis during oxidative stress resides in activation or
induction of protective enzymes. Nuclear-factor-E2-related factor (Nrf)-2 as a member of …

The nuclear factor-erythroid 2-related factor 2 (NRF2) transcription factor plays a central role
in mediating the cellular stress response. Due to their antioxidant properties, compounds …

Transcription factor Nrf2 regulates the basal and inducible expression of detoxifying and
antioxidant genes. Recent studies using nrf2-null mice suggest that Nrf2 dysfunction might …

Regulation of antioxidant gene expression is essential for controlling oxidative stress and
maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a major transcription factor involved in
redox homeostasis and in the response induced by oxidative injury. Nrf2 is present in an …

Myocardial ischemia or reperfusion increases the generation of reactive oxygen species
(ROS) from damaged mitochondria, NADPH oxidases, xanthine oxidase, and inflammation …