Human exposures to environmental toxicants have been associated with etiology of many
diseases including inflammation, cancer, and cardiovascular and neurodegenerative …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an antioxidant-activated cap “n” collar
basic leucine zipper transcription factor. To assess the function of Nrf2 in the antioxidant …

Abstract The" cap'n'collar" bZIP transcription factor Nrf1 heterodimerizes with small Maf
proteins to bind to the Antioxidant Response Element/Electrophile Response Element to …

The Keap1‐Nrf2 system protects animals from oxidative and electrophilic stresses. Nrf2 is a
transcription factor that induces the expression of genes essential for detoxifying reactive …

Neurodegenerative diseases are characterized by the loss of homeostatic functions that
control redox and energy metabolism, neuroinflammation, and proteostasis. The …

NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …

Activation of NF‐E2‐related factor 2 (Nrf2) is a potential therapeutic intervention against
endothelial cell oxidative stress and associated vascular disease. We hypothesized that …

In response to oxidative stress, the transcription factor Nrf2 is upregulated and controls
activation of many genes that work in concert to defend cells from damages and to maintain …

Activation of the transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) is one of
the major cellular defense lines against oxidative and xenobiotic stress, but also influences …

IL-6 gene expression is controlled by a promoter region containing multiple regulatory
elements such as NF-κB, NF-IL6, CRE, GRE, and TRE. In this study, we demonstrated that …