Engineered exosome for drug delivery: recent development and clinical applications

J Tian, Z Han, D Song, Y Peng, M Xiong… - International Journal …, 2023 - Taylor & Francis
Exosomes are nano-sized membrane vesicles that transfer bioactive molecules between
cells and modulate various biological processes under physiological and pathological …

State-of-the-art exosome loading and functionalization techniques for enhanced therapeutics: a review

J Donoso-Quezada, S Ayala-Mar… - Critical reviews in …, 2020 - Taylor & Francis
Exosomes are a subpopulation of cell membrane-derived vesicles which play an essential
role in cellular communication. In recent years, several studies have exploited the natural …

Exosomes as a drug delivery system in cancer therapy: potential and challenges

G Kibria, EK Ramos, Y Wan, DR Gius… - Molecular …, 2018 - ACS Publications
Exosomes play a pivotal role in mediating intercellular communications and package
delivery. They have recently been discovered to serve as diagnostic biomarkers as well as a …

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges

F Mehryab, S Rabbani, S Shahhosseini, F Shekari… - Acta biomaterialia, 2020 - Elsevier
Exosomes are small nanoparticles secreted by almost all cells and have a well-known role
in intercellular communication. They are found in different body fluids and can also be …

Exosomes: Large-scale production, isolation, drug loading efficiency, and biodistribution and uptake

I Kimiz-Gebologlu, SS Oncel - Journal of Controlled Release, 2022 - Elsevier
Exosomes are nanovesicles with different contents that play a role in various biological and
pathological processes. It offers significant advantages over other delivery systems such as …

[HTML][HTML] Review of the isolation, characterization, biological function, and multifarious therapeutic approaches of exosomes

S Gurunathan, MH Kang, M Jeyaraj, M Qasim, JH Kim - Cells, 2019 - mdpi.com
Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

[HTML][HTML] Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

Exosomes as novel bio-carriers for gene and drug delivery

XC Jiang, JQ Gao - International journal of pharmaceutics, 2017 - Elsevier
Clinical treatments have stalled in certain diseases due to a lack of proper therapeutic
delivery systems. Recent studies have identified exosomes for their potential use as cell-free …

Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate

J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …

Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

J Mondal, S Pillarisetti, V Junnuthula, M Saha… - Journal of Controlled …, 2023 - Elsevier
Exosomes are endosome-derived nanovesicles involved in cellular communication. They
are natural nanocarriers secreted by various cells, making them suitable candidates for …