Current knowledge on exosome biogenesis, cargo-sorting mechanism and therapeutic implications

S Xie, Q Zhang, L Jiang - Membranes, 2022 - mdpi.com
Extracellular vesicles (EVs) are nanoscale membrane vesicles released by donor cells that
can be taken up by recipient cells. The study of EVs has the potential to identify unknown …

Advances in exosome-based drug delivery and tumor targeting: from tissue distribution to intracellular fate

J Shao, J Zaro, Y Shen - International journal of nanomedicine, 2020 - Taylor & Francis
Exosomes or small extracellular vesicles are considered a new generation of bioinspired-
nanoscale drug delivery system (DDS). Endogenous exosomes function as signalosomes …

Post isolation modification of exosomes for nanomedicine applications

JL Hood - Nanomedicine, 2016 - Taylor & Francis
Exosomes are extracellular nanovesicles. They innately possess ideal structural and
biocompatible nanocarrier properties. Exosome components can be engineered at the …

Exosomes as drug carriers for cancer therapy

JE Pullan, MI Confeld, JK Osborn, J Kim… - Molecular …, 2019 - ACS Publications
Exosomes, biological extracellular vesicles, have recently begun to find use in targeted drug
delivery in solid tumor research. Ranging from 30–120 nm in size, exosomes are secreted …

Exosome: a significant nano-scale drug delivery carrier

H Peng, W Ji, R Zhao, J Yang, Z Lu, Y Li… - Journal of Materials …, 2020 - pubs.rsc.org
In recent years, due to the limitations of the nature of therapeutic agents, many synthetic
nano-delivery systems have emerged to enhance the efficacy of drugs. Extracellular vesicles …

Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021 - Springer
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules
for intercellular communication. Due to their therapeutic potential, exosomes have been …

Engineering exosomes for cancer therapy

KE Gilligan, RM Dwyer - International journal of molecular sciences, 2017 - mdpi.com
There remains an urgent need for novel therapeutic strategies to treat metastatic cancer,
which results in over 8 million deaths annually worldwide. Following secretion, exosomes …

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

S Sen, J Xavier, N Kumar, MZ Ahmad, OP Ranjan - 3 Biotech, 2023 - Springer
Abstract Exosomes are nanosized (size~ 30–150 nm) natural vesicular structures released
from cells by physiological processes or pathological circumstances. Exosomes are growing …

[HTML][HTML] New advances in exosome-based targeted drug delivery systems

D Ferreira, JN Moreira, LR Rodrigues - Critical Reviews in Oncology …, 2022 - Elsevier
In recent years, various drug nano-delivery platforms have emerged to enhance drug
effectiveness in cancer treatment. However, their successful translation to clinics have been …

Pharmacokinetics of exosomes—an important factor for elucidating the biological roles of exosomes and for the development of exosome-based therapeutics

M Morishita, Y Takahashi, M Nishikawa… - Journal of …, 2017 - Elsevier
Exosomes are small membrane vesicles containing lipids, proteins, and nucleic acids.
Recently, researchers have uncovered that exosomes are involved in various biological …