Development and regulation of exosome‐based therapy products

EV Batrakova, MS Kim - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Recently, various innovative therapies involving the ex vivo manipulation and subsequent
reintroduction of exosome‐based therapeutics into humans have been developed and …

Tumor-targeted exosomes for delivery of anticancer drugs

R Raguraman, D Bhavsar, D Kim, X Ren, V Sikavitsas… - Cancer letters, 2023 - Elsevier
Exosomes are small phospholipid bilayer vesicles that are naturally produced by all living
cells, both prokaryotes and eukaryotes. The exosomes due to their unique size, reduced …

A comprehensive overview of exosomes as drug delivery vehicles—endogenous nanocarriers for targeted cancer therapy

KB Johnsen, JM Gudbergsson, MN Skov… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Exosomes denote a class of secreted nanoparticles defined by size, surface protein and
lipid composition, and the ability to carry RNA and proteins. They are important mediators of …

Recent advancements in the use of exosomes as drug delivery systems

EJ Bunggulawa, W Wang, T Yin, N Wang… - Journal of …, 2018 - Springer
Extracellular vesicles (EVs) are the substances that are released by most types of cells and
have an important role in cell to cell communication. Among the most highly researched EVs …

Targeted delivery of exosomes armed with anti-cancer therapeutics

H Choi, H Yim, C Park, SH Ahn, Y Ahn, A Lee, H Yang… - Membranes, 2022 - mdpi.com
Among extracellular vesicles, exosomes have gained great attention for their role as
therapeutic vehicles for delivering various active pharmaceutical ingredients (APIs) …

[HTML][HTML] A comprehensive review on the composition, biogenesis, purification, and multifunctional role of exosome as delivery vehicles for cancer therapy

J Li, Y Zhang, PY Dong, GM Yang… - Biomedicine & …, 2023 - Elsevier
All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …

Surface functionalization of exosomes for target-specific delivery and in vivo imaging & tracking: Strategies and significance

S Salunkhe, M Basak, D Chitkara, A Mittal - Journal of Controlled …, 2020 - Elsevier
Exosomes are natural nanovesicles excreted by many cells for intercellular communication
and for transfer of materials including proteins, nucleic acids and even synthetic therapeutic …

[HTML][HTML] Exosomes as therapeutic drug carriers and delivery vehicles across biological membranes: current perspectives and future challenges

D Ha, N Yang, V Nadithe - Acta Pharmaceutica Sinica B, 2016 - Elsevier
Exosomes are small intracellular membrane-based vesicles with different compositions that
are involved in several biological and pathological processes. The exploitation of exosomes …

Exosome-mediated delivery of gene vectors for gene therapy

L Duan, L Xu, X Xu, Z Qin, X Zhou, Y Xiao, Y Liang… - Nanoscale, 2021 - pubs.rsc.org
Gene vectors are nucleic acids that carry genetic materials or gene editing devices into cells
to exert the sustained production of therapeutic proteins or to correct erroneous genes of the …

Exosomes as drug carriers in anti-cancer therapy

L Chen, L Wang, L Zhu, Z Xu, Y Liu, Z Li… - Frontiers in Cell and …, 2022 - frontiersin.org
Over the years, there has been a high demand for developing new safe and effective drug
carriers for cancer therapy. Emerging studies have indicated that exosomes can serve as …