Exosome-like systems: nanotechnology to overcome challenges for targeted cancer therapies

J García-Fernández, M de la Fuente Freire - Cancer Letters, 2023 - Elsevier
Exosomes are natural extracellular nanovesicles (30–150 nm in diameter) with the ability to
interact with and be taken up by specific cells. They are being explored as delivery systems …

Exosomes as therapeutics: the implications of molecular composition and exosomal heterogeneity

SW Ferguson, J Nguyen - Journal of Controlled Release, 2016 - Elsevier
Harnessing exosomes as therapeutic drug delivery vehicles requires a better understanding
of exosomal composition and their mode of action. A full appreciation of all the exosomal …

Exosomes: biogenesis, biologic function and clinical potential

Y Zhang, Y Liu, H Liu, WH Tang - Cell & bioscience, 2019 - Springer
Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of
multivesicular bodies and the plasma membrane. They were shown to carry cell-specific …

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

Z Yang, J Xie, J Zhu, C Kang, C Chiang, X Wang… - Journal of Controlled …, 2016 - Elsevier
Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as
extracellular organelles that contain genetic and proteomic information for long distance …

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

W Heusermann, J Hean, D Trojer, E Steib… - Journal of Cell …, 2016 - rupress.org
Exosomes are nanovesicles released by virtually all cells, which act as intercellular
messengers by transfer of protein, lipid, and RNA cargo. Their quantitative efficiency, routes …

Exosome-based smart drug delivery tool for cancer theranostics

R Kar, R Dhar, S Mukherjee, S Nag… - ACS biomaterials …, 2023 - ACS Publications
Exosomes are the phospholipid-membrane-bound subpopulation of extracellular vesicles
derived from the plasma membrane. The main activity of exosomes is cellular …

Engineered exosomes from different sources for cancer-targeted therapy

M Zhang, S Hu, L Liu, P Dang, Y Liu, Z Sun… - Signal transduction and …, 2023 - nature.com
Exosome is a subgroup of extracellular vesicles, which has been serving as an efficient
therapeutic tool for various diseases. Engineered exosomes are the sort of exosomes …

[HTML][HTML] Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs

L Qiao, S Hu, K Huang, T Su, Z Li, A Vandergriff… - Theranostics, 2020 - ncbi.nlm.nih.gov
Cancer is the second leading cause of death worldwide and patients are in urgent need of
therapies that can effectively target cancer with minimal off-target side effects. Exosomes are …

The exosome journey: from biogenesis to uptake and intracellular signalling

S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …

A systematic approach to exosome‐based translational nanomedicine

JL Hood, SA Wickline - Wiley Interdisciplinary Reviews …, 2012 - Wiley Online Library
Exosomes are a type of cell‐derived extracellular nanovesicle. They relay information
between cells. Some known exosome functions include immune modulation, promotion of …