Both pre‐clinical and clinical studies indicate that N‐acetylcysteine (NAC) may be useful in
treating relapse to addictive drug use. Cocaine self‐administration in rats reduces both …

Repeated cocaine treatment produces persistent neuroplasticity in extracellular glutamate
levels in the nucleus accumbens, including a reduction in basal levels and an augmented …

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–
glutamate exchange via system xc−, which maintains glutamate levels and receptor …

Relapse to cocaine-seeking behavior requires an increase in nucleus accumbens (NAc)
core glutamate transmission. Decreased expression of glutamate type I transporter (GLT1) …

ABSTRACT N‐acetylcysteine (NAC) has been suggested to have therapeutic potential in the
treatment of drug addiction through its effects on brain glutamate homeostasis. Here we …

BACKGROUND: The cystine-glutamate exchanger is downregulated after chronic cocaine,
resulting in reduced extracellular levels of nucleus accumbens glutamate. The importance of …

Relapse to cocaine-seeking behavior depends on increased glutamate transmission in key
regions of the mesocorticolimbic motive circuit, including prefrontal cortex (PFC) and …

Addiction is a chronic relapsing disorder hypothesized to be produced by drug-induced
plasticity that renders individuals vulnerable to craving-inducing stimuli such as re-exposure …

Repeated cocaine treatment and withdrawal produces changes in brain function thought to
be involved in relapse to drug use. Withdrawal from repeated cocaine reduced in vivo …

Cocaine produces a persistent reduction in cystine–glutamate exchange via system xc− in
the nucleus accumbens that may contribute to pathological glutamate signaling linked to …