Publisher Summary This chapter describes a rabbit model of bacterial endocarditis, in which
the white New Zealand female rabbits weighing 2–2.5 kg are the most commonly used. The …

Numerous important observations concerning the pathogenesis of infective endocarditis
have been made over the past 18 years. Many of these observations have been obtained …

The results of studies performed with animal models of experimental infective endocarditis
have provided valuable information about the pathophysiology, natural history, and …

A simple model of infective endocarditis was produced in rats. With the aid of a guide wire,
polyethylene catheters were passed into the left ventricle through the right carotid artery of …

In 1970 Freedman and co-workers presented a reproducible, simple and inexpensive
animal model of endocarditis based on an insertion of an indweUingcatheter inside the …

Bacterial endocarditis is a difficult-to-curc infection, owing to (i) poor penetration of
antibiotics into infected vegetations;(ii) altered metabolic state of bacteria within the …

Experimental Methods Two general systems of experimentation have evolved. In the first,
normal animals are used; in the second, the animals are subjected to some procedure …

Infective endocarditis (IE) has been studied in several experimental animal models,
including the dog, lo rat, 3 rabbit, 2, 10 opossum9 and A simple intravenous injection into …

Experimental models of infective endocarditis antedate Garrison and Freedman's work in
1970. The hypothesis of the role of parasites (microorganisms) microscopically observed in …

A simple and reliable model for endocarditis in rabbits has been studied and standardized.
Non-bacterial thrombotic endocarditis was produced on either side of the heart by the …