The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines
L Li, J Perdigao, AE Pegg, Y Lao… - Chemical research in …, 2009 - ACS Publications
Tobacco-specific nitrosamines, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N′-
nitrosonornicotine, are considered to be human carcinogens. Both compounds are …
nitrosonornicotine, are considered to be human carcinogens. Both compounds are …
O6-Pyridyloxobutylguanine Adducts Contribute to the Mutagenic Properties of Pyridyloxobutylating Agents
RS Mijal, NA Loktionova, CC Vu, AE Pegg… - Chemical research in …, 2005 - ACS Publications
The tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N '-nitrosonornicotine (NNN) are potent carcinogens in animal models and likely human …
and N '-nitrosonornicotine (NNN) are potent carcinogens in animal models and likely human …
Formation, repair, and genotoxic properties of bulky DNA adducts formed from tobacco‐specific nitrosamines
LA Peterson - Journal of nucleic acids, 2010 - Wiley Online Library
4‐(Methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) and N′‐nitrosonornicotine (NNN)
are tobacco‐specific nitrosamines present in tobacco products and smoke. Both compounds …
are tobacco‐specific nitrosamines present in tobacco products and smoke. Both compounds …
Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated …
M Wang, G Cheng, SJ Sturla, Y Shi… - Chemical research in …, 2003 - ACS Publications
The tobacco specific carcinogens 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
and N '-nitrosonornicotine (NNN) are metabolically activated to 4-oxo-4-(3-pyridyl)-1 …
Quantification of DNA Lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in mammalian cells
Quantitative measurement of DNA adducts in carcinogen-exposed cells provides the
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
information about the frequency of formation and the rate of removal of DNA lesions in vivo …
The Pyridyloxobutyl DNA Adduct, O6-[4-Oxo-4-(3-pyridyl)butyl]guanine, Is Detected in Tissues from 4-(Methylnitrosamino)- 1-(3-pyridyl)-1-butanone-treated A/J Mice
NM Thomson, PM Kenney… - Chemical research in …, 2003 - ACS Publications
The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
a potent pulmonary carcinogen. This unsymmetric nitrosamine can be metabolically …
Repair of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA pyridyloxobutylation by nucleotide excision repair
PJ Brown, LL Bedard, TE Massey - Cancer Letters, 2008 - Elsevier
The tobacco-specific lung carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
(NNK) forms DNA methylating and pyridyloxobutylating species. In this study, the …
(NNK) forms DNA methylating and pyridyloxobutylating species. In this study, the …
Mass spectrometric analysis of relative levels of pyridyloxobutylation adducts formed in the reaction of DNA with a chemically activated form of the tobacco-specific …
SJ Sturla, J Scott, Y Lao, SS Hecht… - Chemical research in …, 2005 - ACS Publications
Exposure to the tobacco-related nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and N '-nitrosonornicotine is carcinogenic to humans. Metabolic activation …
butanone (NNK) and N '-nitrosonornicotine is carcinogenic to humans. Metabolic activation …
Quantitation of pyridyloxobutyl DNA adducts of tobacco-specific nitrosamines in rat tissue DNA by high-performance liquid chromatography− electrospray ionization …
Y Lao, PW Villalta, SJ Sturla, M Wang… - Chemical research in …, 2006 - ACS Publications
The tobacco-specific nitrosamines N '-nitrosonornicotine (NNN, 1) and 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK, 2) are potent carcinogens in rodents …
Development of a quantitative liquid chromatography/electrospray mass spectrometric assay for a mutagenic tobacco specific nitrosamine-derived DNA adduct, O 6-[4 …
NM Thomson, RS Mijal, R Ziegel… - Chemical research in …, 2004 - ACS Publications
Liquid chromatography with electrospray tandem mass spectrometry (LC/ESI-MS/MS) was
employed to quantify O 6-[4-oxo-4-(3-pyridyl) butyl]-2 '-deoxyguanosine (O 6-pobdG), a …
employed to quantify O 6-[4-oxo-4-(3-pyridyl) butyl]-2 '-deoxyguanosine (O 6-pobdG), a …