Meiotic induction in cumulus cell-enclosed mouse oocytes: involvement of the pentose phosphate pathway
SM Downs, PG Humpherson… - Biology of …, 1998 - academic.oup.com
In this study we tested the hypothesis that the pentose phosphate pathway (PPP)
participates in the meiotic induction of mouse oocytes. The electron acceptors methylene …
participates in the meiotic induction of mouse oocytes. The electron acceptors methylene …
Involvement of purine nucleotide synthetic pathways in gonadotropin‐induced meiotic maturation in mouse cumulus cell‐enclosed oocytes
SM Downs - Molecular Reproduction and Development …, 1997 - Wiley Online Library
This study was carried out to test the hypothesis that purine nucleotide‐generating pathways
are required for ligand‐stimulated oocyte maturation in meiotically arrested cumulus cell …
are required for ligand‐stimulated oocyte maturation in meiotically arrested cumulus cell …
Substrate utilization and maturation of cumulus cell-enclosed mouse oocytes: evidence that pyruvate oxidation does not mediate meiotic induction
SM Downs, FD Houghton, PG Humpherson… - …, 1997 - rep.bioscientifica.com
This study was performed to address the possible role of pyruvate in meiotic induction in
mouse oocytes. Cumulus cell-enclosed oocytes from primed, immature mice were cultured …
mouse oocytes. Cumulus cell-enclosed oocytes from primed, immature mice were cultured …
Oxidative metabolism of pyruvate is required for meiotic maturation of murine oocytes in vivo
MT Johnson, EA Freeman, DK Gardner… - Biology of …, 2007 - academic.oup.com
The requirement for oxidative metabolism of pyruvate during oogenesis in vivo was
evaluated by inactivating Pdha1, a gene encoding an enzymatic subunit of pyruvate …
evaluated by inactivating Pdha1, a gene encoding an enzymatic subunit of pyruvate …
Metabolism of radiolabeled glucose by mouse oocytes and oocyte-cumulus cell complexes
SM Downs, AM Utecht - Biology of reproduction, 1999 - academic.oup.com
This study was carried out to examine the metabolism of [1-14C]-,[6-14C]-, and [5-3H]
glucose by oocyte-cumulus cell complexes (OCC) and denuded oocytes (DO) and to test the …
glucose by oocyte-cumulus cell complexes (OCC) and denuded oocytes (DO) and to test the …
Culture conditions affect meiotic regulation in cumulus cell‐enclosed mouse oocytes
SM Downs, AM Mastropolo - Molecular Reproduction and …, 1997 - Wiley Online Library
To test the hypothesis that culture conditions influence meiotic regulation in mouse oocytes,
we have examined the effects of six culture media, four organic buffers, and pH on …
we have examined the effects of six culture media, four organic buffers, and pH on …
Induction of mouse oocyte maturation in vivo by perturbants of purine metabolism
SM Downs, JJ Eppig - Biology of reproduction, 1987 - academic.oup.com
Previous studies have suggested a critical role for purines in the maintenance of mouse
oocytes in meiotic arrest. If so, then disrupting specific purine metabolic pathways in vivo …
oocytes in meiotic arrest. If so, then disrupting specific purine metabolic pathways in vivo …
Chemical manipulation of glucose metabolism in porcine oocytes: effects on nuclear and cytoplasmic maturation in vitro
JR Herrick, AM Brad, RL Krisher - Reproduction, 2006 - rep.bioscientifica.com
The objectives of this study were to manipulate metabolism of glucose through glycolysis
and the pentose phosphate pathway (PPP) in porcine oocytes during in vitro maturation, and …
and the pentose phosphate pathway (PPP) in porcine oocytes during in vitro maturation, and …
Requirement for glucose in ligand-stimulated meiotic maturation of cumulus cell-enclosed mouse oocytes
CF Fagbohun, SM Downs - Reproduction, 1992 - rep.bioscientifica.com
In this study, the effect of different energy sources used in Eagle's minimum essential
medium on the meiotic maturation of mouse oocytes in culture was examined. The effects of …
medium on the meiotic maturation of mouse oocytes in culture was examined. The effects of …
Effect of phosphodiesterase type 3 inhibitor on developmental competence of immature mouse oocytes in vitro
D Nogueira, R Cortvrindt, DG De Matos… - Biology of …, 2003 - academic.oup.com
In vitro use of arresters of meiosis could improve cytoplasmic maturation of immature
oocytes by controlling the period of prophase I. Phosphodiesterases (PDE) are responsible …
oocytes by controlling the period of prophase I. Phosphodiesterases (PDE) are responsible …
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