Dopaminergic mechanisms of individual differences in human effort-based decision-making

MT Treadway, JW Buckholtz, RL Cowan… - Journal of …, 2012 - Soc Neuroscience
Preferences for different combinations of costs and benefits are a key source of variability in
economic decision-making. However, the neurochemical basis of individual differences in …

The role of the striatum in effort-based decision-making in the absence of reward

N Schouppe, J Demanet, CN Boehler… - Journal of …, 2014 - Soc Neuroscience
Decision-making involves weighing costs against benefits, for instance, in terms of the effort
it takes to obtain a reward of a given magnitude. This evaluation process has been linked to …

Neurocomputational mechanisms underlying subjective valuation of effort costs

TTJ Chong, M Apps, K Giehl, A Sillence, LL Grima… - PLoS …, 2017 - journals.plos.org
In everyday life, we have to decide whether it is worth exerting effort to obtain rewards. Effort
can be experienced in different domains, with some tasks requiring significant cognitive …

Amping up effort: effects of d-amphetamine on human effort-based decision-making

MC Wardle, MT Treadway, LM Mayo… - Journal of …, 2011 - Soc Neuroscience
Animal studies suggest the neurotransmitter dopamine (DA) plays an important role in
decision-making. In rats, DA depletion decreases tolerance for effort and probability costs …

Dopamine, effort-based choice, and behavioral economics: basic and translational research

JD Salamone, M Correa, JH Yang, R Rotolo… - Frontiers in behavioral …, 2018 - frontiersin.org
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental …

Calculating utility: preclinical evidence for cost–benefit analysis by mesolimbic dopamine

PEM Phillips, ME Walton, TC Jhou - Psychopharmacology, 2007 - Springer
Rationale Throughout our lives we constantly assess the costs and benefits of the possible
future outcomes of our actions and use this information to guide behavior. There is …

Motivational states influence effort-based decision making in rats: the role of dopamine in the nucleus accumbens

B Mai, S Sommer, W Hauber - Cognitive, Affective, & Behavioral …, 2012 - Springer
Decision-making policies are subject to modulation by changing motivational states.
However, so far, little is known about the neurochemical mechanisms that bridge …

Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making

SB Floresco, JRS Onge, S Ghods-Sharifi… - Cognitive, Affective, & …, 2008 - Springer
Research on the neural basis that underlies decision making in humans has revealed that
these processes are mediated by distributed neural networks that incorporate different …

Effort-based decision making in the rat: an [18F] fluorodeoxyglucose micro positron emission tomography study

H Endepols, S Sommer, H Backes… - Journal of …, 2010 - Soc Neuroscience
Decision making refers to the process by which subjects choose between competing
courses of action based on the expected costs and benefits of their consequences. Lesion …

Neural signatures of value comparison in human cingulate cortex during decisions requiring an effort-reward trade-off

MC Klein-Flügge, SW Kennerley, K Friston… - Journal of …, 2016 - Soc Neuroscience
Integrating costs and benefits is crucial for optimal decision-making. Although much is
known about decisions that involve outcome-related costs (eg, delay, risk), many of our …