NSAID inhibition of GI cancer growth: clinical implications and molecular mechanisms of action

SS Husain, IL Szabo, AS Tarnawski - Official journal of the …, 2002 - journals.lww.com
Epidemiological studies suggest that aspirin and other nonsteroidal anti-inflammatory drugs
(NSAIDs) reduce the incidence of and mortality from colorectal, gastric, and esophageal …

Non-steroidal anti-inflammatory drugs and the chemoprevention of colorectal and oesophageal cancers.

G Morgan - Gut, 1996 - ncbi.nlm.nih.gov
In recent years, several areas of biological research have increasingly supported the
suggestion that aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) may …

Extent, mode, and dose dependence of anticancer effects

R Sjödahl - The American journal of medicine, 2001 - Elsevier
Regular intake of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) is
associated with a decreased incidence of colorectal, esophageal, gastric, and lung cancer …

NSAIDs and chemoprevention

CV Rao, BS Reddy - Current cancer drug targets, 2004 - ingentaconnect.com
Several epidemiological, clinical and experimental studies established nonsteroidal anti-
inflammatory drugs (NSAIDs) as promising cancer chemopreventive agents. Long-term use …

Nonsteroidal anti-inflammatory drugs, COX-2 and colorectal cancer

P Patrignani - Toxicology letters, 2000 - Elsevier
Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) has been
associated with reduced risk of colorectal cancer. Moreover, the NSAID sulindac reduces the …

Cyclooxygenase-2 and gastrointestinal cancer

JR Mann, RN DuBois - The Cancer Journal, 2004 - journals.lww.com
The cyclooxygenase (COX) enzymes (COX-1 and COX-2) are key enzymes of prostaglandin
(PG) biosynthesis. Nonselective non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the …

Nonsteroidal anti-inflammatory drugs and cancer prevention

JA Baron, RS Sandler - Annual review of medicine, 2000 - annualreviews.org
▪ Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs), including aspirin, appear to have
clinically significant anticarcinogenic effects in the gastrointestinal tract. Epidemiological …

Use of NSAIDs for the chemoprevention of colorectal cancer

JM Herendeen, C Lindley - Annals of Pharmacotherapy, 2003 - journals.sagepub.com
OBJECTIVE: To discuss the role of nonsteroidal antiinflammatory drugs (NSAIDs) in the
chemoprevention of colorectal cancer. DATA SOURCES: A MEDLINE search (1966–May …

Colon cancer: a role for cyclo-oxygenase-2-specific nonsteroidal anti-inflammatory drugs

BS Reddy, CV Rao - Drugs & aging, 2000 - Springer
Large bowel cancer is not only the third most frequent cancer in the world but is one of the
most common human malignancies in Western countries, including North America. In recent …

Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer

N Arber, RN DuBois - Current gastroenterology reports, 1999 - Springer
Increasing evidence suggests that aspirin and other nonsteroidal anti-inflammatory drugs
(NSAIDs) reduce the risk of colorectal cancer. This observation is supported by results from …