Role of distinct natural killer cell subsets in anticancer response

H Stabile, C Fionda, A Gismondi, A Santoni - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells, the prototypic member of innate lymphoid cells, are important
effectors of anticancer immune response. These cells can survey and control tumor initiation …

The molecular mechanism of natural killer cells function and its importance in cancer immunotherapy

S Paul, G Lal - Frontiers in immunology, 2017 - frontiersin.org
Natural killer (NK) cells are innate immune cells that show strong cytolytic function against
physiologically stressed cells such as tumor cells and virus-infected cells. NK cells show a …

Natural killer cells in human cancer: from biological functions to clinical applications

EM Levy, MP Roberti, J Mordoh - BioMed Research …, 2011 - Wiley Online Library
Natural killer (NK) cells are central components of the innate immunity. In murine models, it
has been shown that NK cells can control both local tumor growth and metastasis due to …

A pan-cancer single-cell panorama of human natural killer cells

F Tang, J Li, L Qi, D Liu, Y Bo, S Qin, Y Miao, K Yu… - Cell, 2023 - cell.com
Natural killer (NK) cells play indispensable roles in innate immune responses against tumor
progression. To depict their phenotypic and functional diversities in the tumor …

Plasticity of NK cells in Cancer

D Corvino, A Kumar, T Bald - Frontiers in Immunology, 2022 - frontiersin.org
Natural killer (NK) cells are crucial to various facets of human immunity and function through
direct cytotoxicity or via orchestration of the broader immune response. NK cells exist across …

Therapeutic potential and challenges of natural killer cells in treatment of solid tumors

A Gras Navarro, AT Björklund, M Chekenya - Frontiers in immunology, 2015 - frontiersin.org
Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective
immunotherapy for a broad range of cancers. Due to the mode of NK cell killing, requiring …

Tumor-and cytokine-primed human natural killer cells exhibit distinct phenotypic and transcriptional signatures

M Sabry, A Zubiak, SP Hood, P Simmonds… - PLoS …, 2019 - journals.plos.org
An emerging cellular immunotherapy for cancer is based on the cytolytic activity of natural
killer (NK) cells against a wide range of tumors. Although in vitro activation, or “priming,” of …

Tumor-primed NK cells: waiting for the green light

M Sabry, MW Lowdell - Frontiers in Immunology, 2013 - frontiersin.org
The functional impairment of natural killer (NK) cells has been frequently reported in cancer
studies. As one of the central components of host anti-tumor immunity, NK cells exert cellular …

Cytokines orchestrating the natural killer-myeloid cell crosstalk in the tumor microenvironment: implications for natural killer cell-based cancer immunotherapy

S Gaggero, K Witt, M Carlsten, S Mitra - Frontiers in immunology, 2021 - frontiersin.org
Natural killer (NK) cells are endowed with germline-encoded receptors that enable them to
detect and kill malignant cells without prior priming. Over the years, overwhelming evidence …

Natural killer cells target and differentiate cancer stem-like cells/undifferentiated tumors: strategies to optimize their growth and expansion for effective cancer …

K Kaur, MP Nanut, MW Ko, T Safaie, J Kos… - Current opinion in …, 2018 - Elsevier
Highlights•NK cells are effectors of selection and differentiation of CSCs/undifferentiated
tumors.•Induction of split anergy in NK cells is a mechanism for differentiation of tumor …