Background Sepsis is a leading cause of mortality and critical illness worldwide and is
associated with an increased mortality rate in the months following hospital discharge. The …

Introduction Hospital-acquired pneumonia after surgery is one of the major causes of septic
shock. The excessive inflammatory response appears to be responsible for the increased …

Purpose The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill
patients remains an understudied area. Previous studies have identified that acute tubular …

Background Septic shock is the most severe complication of sepsis and this syndrome is
associated with high mortality. Treatment of septic shock remains largely supportive of …

Background Biomarkers of disease severity might help individualizing the management of
patients with the acute respiratory distress syndrome (ARDS). Whether the alveolar …

Background Bloodstream infections of abdominal origin are usually associated with poor
prognosis. We assessed the clinical and microbiological characteristics of critically ill …

Introduction It has recently been proposed that B lymphocytes are involved in sepsis
pathogenesis. The goal of this study is to investigate potential abnormalities in a subset …

Introduction Sepsis-induced immunosuppression may result in death. The mechanisms of
immune suppression include loss of macrophage and monocyte expression of the major …

Introduction Although major changes of the immune system have been described in sepsis,
it has never been studied whether these may differ in relation to the type of underlying …

Introduction Severe sepsis is characterized by an initial hyper-inflammatory response that
may progress to an immune-suppressed state associated with increased susceptibility to …