Introduction Recent models capturing the pathophysiology of sepsis and ex-vivo data from
patients are speculating about immunosuppression in the so-called late phase of sepsis …

Introduction Endothelial damage accounts greatly for the high mortality in septic shock.
Higher expression of mediators (IL-6, IL-8, soluble intercellular adhesion molecule 1 [sICAM …

Introduction Cardiogenic shock (CS) remains the leading cause of death in patients
hospitalized for myocardial infarction (MI). Systemic inflammation with inappropriate …

Background Sepsis is characterized by a dysregulated immune response to infection. The
complement system plays an important role in the host defence to pathogens. However …

Methods We developed an ELISA using two rat monoclonal antibodies against N-terminal
and C-terminal peptide sequences of rabbit sCD14-ST, respectively, to determine sCD14-ST …

Introduction ICU-acquired muscle weakness commonly occurs in patients with septic shock
and is associated with poor outcome. Although atrophy is known to be involved, it is unclear …

Introduction Indications for renal replacement therapy (RRT) have not been generally
standardized and vary among intensive care units (ICUs). We aimed to assess the …

Objective Approximately one-third of sepsis patients experience poor outcomes including
chronic critical illness (CCI, intensive care unit (ICU) stay> 14 days) or early death (in …

Introduction Delirium is a common occurrence in critically ill patients and is associated with
an increase in morbidity and mortality. Septic patients with delirium may differ from a general …

Introduction Sepsis is a complex immunological response to infection characterized by early
hyper-inflammation followed by severe and protracted immunosuppression, suggesting that …