The Shc family of docking proteins plays an essential role in leading cellular signaling to
specific downstream molecules such as the Ras-ERK pathway and the phosphatidylinositol …

Androgens play an important role in male reproductive development and function. These
steroid hormones mediate their actions by binding to the androgen receptor (AR). Diseases …

The androgen receptor protein has specific domains involved in DNA binding, ligand
binding, and transactivation, whose activities need to be integrated during transcription …

Nuclear receptor (NR)-mediated transcriptional activity is a dynamic process that is
regulated by the binding of ligands that induce distinct conformational changes in the NR …

Although androgen receptor levels vary widely during development, our previous studies
have suggested that a single promoter is active in a number of human and rat tissues and …

The classical action of androgen receptor (AR) is to regulate gene transcriptional processes
via AR nuclear translocation, response element binding and recruitment of, or crosstalk with …

Chromatin immunoprecipitation (ChIP) is an invaluable tool in the study of transcriptional
regulation. ChIP methods require both a priori knowledge of the transcriptional regulators …

Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

The androgen receptor (AR) is a member of the nuclear receptor superfamily, members of
which function as ligand-inducible transcription factors that mediate the expression of target …

Androgens exert most of their biological activities through binding to the androgen receptor
(AR). The AR belongs to the nuclear receptor superfamily and acts as a ligand-inducible …