Osteosarcoma is the most frequent second primary cancer occurring during the first 20 years
following treatment for a solid cancer in childhood. Using a cohort study of children treated …

We estimated the risk of subsequent bone cancer among 9170 patients who had survived
two or more years after the diagnosis of a cancer in childhood. As compared with the …

Bone sarcoma as a second malignancy is rare but highly fatal. The present knowledge
about radiation-absorbed organ dose–response is insufficient to predict the risks induced by …

PURPOSE: We analyzed the clinical features and outcome of patients with radiation-
associated osteosarcoma treated during the era of contemporary chemotherapy. PATIENTS …

Soft tissue sarcoma (STS) is one of the most frequent second primary cancer that occurs
during the first 20 years following treatment for a solid cancer in childhood. Our aim was to …

Background Individuals who had cancer in childhood are at higher risk of developing bone
cancer than any other type of second primary cancer. Purpose Using the population-based …

We evaluated the rate of second malignancies in 1205 patients with osteosarcoma of the
extremity treated at our Institution with different protocols of adjuvant and neoadjuvant …

Purpose: Radiation-induced osteosarcomas (R-OS) have historically been high-grade,
locally invasive tumors with a poor prognosis. The purpose of this study was to perform a …

Nine patients who had an osteosarcoma that had developed as a second malignant
neoplasm in a previously irradiated site were managed at a major center for the treatment of …

Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …