Cancer is still a major concern for public health and is a cause of death while being
psychologically the most dreaded disease. Until recent times, the diagnosis of a progressed …

In classical models of tumorigenesis, the accumulation of tumor promoting chromosomal
aberrations is described as a gradual process. Next-generation sequencing-based methods …

Cancer models have helped solve many mysteries of cancer research, and are poised to
bring our understanding to the next level as we dissect the relevance of cancer-associated …

Cancer is a complex and uniquely personal disease. More than 1.7 million people in the
United States are diagnosed with cancer every year. As the burden of cancer grows, so does …

Cancer models are indispensable research tools for elucidating the mechanisms involved in
tumor onset, progression and treatment resistance. They are key in evaluating therapeutics …

Complex chromosomal rearrangements such as translocations play a critical role in
oncogenesis. Translocation detection is vital to decipher their biological role in activating …

Human cancer is a complex and heterogeneous collection of diseases that kills more than
18 million people every year worldwide. Despite advances in detection, diagnosis, and …

Motivation Eukaryotic chromosomes adapt a complex and highly dynamic three-dimensional
(3D) structure, which profoundly affects different cellular functions and outcomes including …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Modeling, an experimental approach to investigate complex biological systems, has
significantly contributed to our understanding of cancer. Although extensive cancer research …