Circulating microbiota-based metagenomic signature for detection of hepatocellular carcinoma

EJ Cho, S Leem, SA Kim, J Yang, YB Lee, SS Kim… - Scientific reports, 2019 - nature.com
Circulating microbial dysbiosis is associated with chronic liver disease including
nonalcoholic steatohepatitis and alcoholic liver disease. In this study, we evaluated whether …

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

Z Ren, A Li, J Jiang, L Zhou, Z Yu, H Lu, H Xie, X Chen… - Gut, 2019 - gut.bmj.com
Objective To characterise gut microbiome in patients with hepatocellular carcinoma (HCC)
and evaluate the potential of microbiome as non-invasive biomarkers for HCC. Design We …

Identification reproducible microbiota biomarkers for the diagnosis of cirrhosis and hepatocellular carcinoma

H Zhang, J Wu, Y Liu, Y Zeng, Z Jiang, H Yan, J Lin… - AMB Express, 2023 - Springer
Hepatocellular carcinoma (HCC) is a malignant tumor with high incidence in China, which is
mainly related to chronic hepatitis B (CHB) and liver cirrhosis (LC) caused by hepatitis B …

Human microbiome is a diagnostic biomarker in hepatocellular carcinoma

BC Rao, JM Lou, WJ Wang, A Li, GY Cui, ZJ Yu… - … & Pancreatic Diseases …, 2020 - Elsevier
Background Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality
worldwide. Increasing evidence indicates a close relationship between HCC and the human …

Gut microbiome alteration as a diagnostic tool and associated with inflammatory response marker in primary liver cancer

T Deng, J Li, B He, B Chen, F Liu, Z Chen… - Hepatology …, 2022 - Springer
Background Primary liver cancer has high mortality and morbidity worldwide. However, the
characteristic of gut microbiota profile and its correlation with inflammation status in liver …

A distinct microbiota signature precedes the clinical diagnosis of hepatocellular carcinoma

J Yang, Q He, F Lu, K Chen, ZH Ni, H Wang, C Zhou… - Gut …, 2023 - Taylor & Francis
Oral, gut, and tumor microbiota have been implicated as important regulators in the
carcinogenesis and progression of gastrointestinal malignancies. However, few studies …

[HTML][HTML] Hepatic stellate cell activation and senescence induced by intrahepatic microbiota disturbances drive progression of liver cirrhosis toward hepatocellular …

B Liu, Z Zhou, Y Jin, J Lu, D Feng, R Peng… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Background The significance of the relationship between the microbiota and diseases is
increasingly being recognized. However, the characterization of tumor microbiome and their …

The intratumoral bacterial metataxonomic signature of hepatocellular carcinoma

JH Huang, J Wang, XQ Chai, ZC Li… - Microbiology …, 2022 - Am Soc Microbiol
Microbiota is implicated in hepatocellular carcinoma (HCC). The spectrum of intratumoral
microbiota associated with HCC progression remains elusive. Fluorescence in situ …

A gut bacterial signature in blood and liver tissue characterizes cirrhosis and hepatocellular carcinoma

M Effenberger, S Waschina, C Bronowski… - Hepatology …, 2023 - journals.lww.com
Background: HCC is the leading cause of cancer in chronic liver disease. A growing body of
experimental mouse models supports the notion that gut-resident and liver-resident …

Abnormal fecal microbiota community and functions in patients with hepatitis B liver cirrhosis as revealed by a metagenomic approach

X Wei, X Yan, D Zou, Z Yang, X Wang, W Liu… - BMC …, 2013 - Springer
Background Assessment and characterization of human colon microbiota is now a major
research area in human diseases, including in patients with hepatitis B liver cirrhosis …