Frontal cortical regions are activated by food-associated stimuli, and this activation appears
to be dysregulated in individuals with eating disorders. Nevertheless, frontal control of basic …

Rationale Whereas reward-modulatory opioid actions have been intensively studied in
subcortical sites such as the nucleus accumbens (Acb), the role of cortical opioid …

Activation of μ-opioid receptors makes animals hyperphagic and increases their preference
for a high-fat diet. Previous studies have suggested that this receptor population plays a role …

Food reward can be driven by separable mechanisms of hedonic impact (food 'liking') and
incentive motivation (food 'wanting'). Brain mu-opioid systems contribute crucially to both …

Our previous studies have shown that stimulation of mu-opioid receptors within the nucleus
accumbens preferentially enhances intake of palatable food containing sucrose and fat; …

Endogenous opioids are involved in the hedonic aspects of eating. Opioid impairments and
alterations have been implicated in the pathophysiology of bulimia nervosa and binge …

Binge eating disorder is an addiction‐like disorder characterized by excessive food
consumption within discrete periods of time. This study was aimed at understanding the role …

Overindulgence in easily available energy-dense palatable foods is thought to be an
important factor in the current obesity epidemic but the underlying neural mechanisms are …

Infusion of a μ-opioid receptor (MOR) agonist into the nucleus accumbens (NAcc) drives
voracious food intake, an effect hypothesized to occur through increased tastant palatability …

Opioid transmission and dysregulated prefrontal cortex (PFC) activity have both been
implicated in the inhibitory-control deficits associated with addiction and binge-type eating …