The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of
desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine …

The asialoglycoprotein receptor (ASGPR), an endocytotic cell surface receptor expressed by
hepatocytes, is triggered by triantennary binding to galactose residues of macromolecules …

The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor
expressed on hepatocytes that binds its native substrates with low affinity. More potent …

Transport of macromolecules into the cell by receptor-mediated endocytosis follows a
complex series of intracellular transfers, passing through distinct environments. The …

The mammalian asialoglycoprotein receptor (ASGPR) is located on the sinusoidal
membrane of hepatocytes where it binds and endocytoses galactose-terminated …

We have used combinations of subcellular fractionation, specific cytochemical tracers, and
quantitative immunoadsorption to determine when, where, and in which intracellular …

The endocytic compartments of the asialoglycoprotein (ASGP) pathway in rat hepatocytes
were studied using a combined morphological and biochemical approach in the isolated …

In order to develop the non-viral Bioplex vector system for targeted delivery of genes to
hepatocytes, we have evaluated the structure-function relationship for a number of synthetic …

Standard pharmacologic approaches to liver diseases have been frustrated by inadequate
delivery of active agents into liver cells as well as nonspecific toxicity towards other organs …

A series of novel, fluorescent ligands designed to bind with high affinity and specificity to the
asialoglycoprotein receptor (ASGP-R) has been synthesized and tested on human liver …