MUTYH is a base excision repair (BER) enzyme that prevents mutations in DNA associated
with 8-oxoguanine (OG) by catalyzing the removal of adenine from inappropriately formed …

The aim of this study was to determine the pan-cancer landscape of MUTYH alterations and
the relationship between MUTYH mutations and potentially actionable biomarkers such as …

Approximately 18% of ovarian cancers have an underlying genetic predisposition and many
of the genetic alterations have become intervention and therapy targets. Although mutations …

Abstract Background Histocompatibility minor 13 (HM13) is a signal sequence stubbed
intramembrane cleavage catalytic protein that is essential for cell signaling, intracellular …

Adenocarcinoma of esophagus (AE) is a complex disease, affected by a variety of genetic
and environmentalfactors. Much evidence has shown that the MutY glycosylase homologue …

Colorectal cancer (CRC) is the most common digestive tumor in the world and has a high
mortality rate. The development and treatment of CRC are related to the immune …

Inflammation-associated oxidative stress and DNA damage are involved in malignant
transformation of cholangiocytes. Defective DNA repair mechanisms may predispose to …

Introduction Hepatocellular carcinoma (HCC) is one of the most common malignant tumours
in the world and has a high mortality rate. However, the pathogenesis of HCC remains …

Biallelic germline mutations in the base excision repair enzyme gene MUTYH lead to
multiple colorectal adenomas and carcinomas referred to as MUTYH-associated polyposis …

Background To explore the expression of hyaluronan mediated motility receptor (HMMR) in
lung adenocarcinoma (LUAD) and its relationship with clinicopathological features and …