Spatial transcriptomics reveals substantial heterogeneity in triple negative breast cancer with potential clinical implications
While triple negative breast cancer (TNBC) is known to be heterogeneous at the genomic
and transcriptomic levels, spatial information on tumor organization and cell composition is …
and transcriptomic levels, spatial information on tumor organization and cell composition is …
1711P Spatial transcriptomics reveals substantial heterogeneity in TNBC tumor and stroma compartments with potential clinical implications
X Wang, D Venet, F Lifrange, D Larsimont… - Annals of …, 2022 - annalsofoncology.org
Background Triple negative breast cancer (TNBC) is a heterogeneous disease
characterized by at least five molecular subtypes, namely basal like (BL) …
characterized by at least five molecular subtypes, namely basal like (BL) …
Spatial transcriptomic analysis of a diverse patient cohort reveals a conserved architecture in triple-negative breast cancer
R Bassiouni, MO Idowu, LD Gibbs, V Robila… - Cancer research, 2023 - AACR
Triple-negative breast cancer (TNBC) is an aggressive disease that disproportionately
affects African American (AA) women. Limited targeted therapeutic options exist for patients …
affects African American (AA) women. Limited targeted therapeutic options exist for patients …
[PDF][PDF] Unraveling triple-negative breast cancer tumor microenvironment heterogeneity: towards an optimized treatment approach
Background Recent efforts of gene expression profiling analyses recognized at least four
different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known …
different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known …
50 Spatially resolved molecular investigation of triple negative breast cancer and its immune microenvironment
S Williams, C Uytingco, N Weisenfeld, N Delaney… - 2020 - jitc.bmj.com
Background Triple negative breast cancer (TNBC) accounts for 10–20% of all diagnosed
breast cancer cases in the US and is characterized by loss of HER2, estrogen receptors, and …
breast cancer cases in the US and is characterized by loss of HER2, estrogen receptors, and …
[HTML][HTML] Spatial and Compositional Biomarkers in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited
treatment options, which warrants identification of novel therapeutic targets. Deciphering …
treatment options, which warrants identification of novel therapeutic targets. Deciphering …
[HTML][HTML] Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysis
W Cheng, W Mi, S Wang, X Wang, H Jiang… - Journal of …, 2024 - Elsevier
Breast cancer remains a leading cause of mortality in women worldwide. Triple-negative
breast cancer (TNBC) is a particularly aggressive subtype characterized by rapid …
breast cancer (TNBC) is a particularly aggressive subtype characterized by rapid …
Comprehensive spatial transcriptomic analysis of an integrated, diverse cohort reveals distinct molecular topographic patterns in triple negative breast cancer
R Bassiouni, M Idowu, LD Gibbs, PJ Grizzard… - Cancer Research, 2022 - AACR
Background: Triple negative breast cancer (TNBC) is an aggressive subtype of breast
cancer that disproportionately affects African-American and black (AAB) women, who have …
cancer that disproportionately affects African-American and black (AAB) women, who have …
[PDF][PDF] A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer. Cancers 2021, 13, 316
I Nederlof, HM Horlings, C Curtis, M Kok - 2021 - info.submit4journal.com
Providing effective personalized immunotherapy for triple negative breast cancer (TNBC)
patients requires a detailed understanding of the composition of the tumor …
patients requires a detailed understanding of the composition of the tumor …
[HTML][HTML] Unraveling heterogeneity of tumor cells and microenvironment and its clinical implications for triple negative breast cancer
K Jiang, M Dong, C Li, J Sheng - Frontiers in Oncology, 2021 - frontiersin.org
Objective: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer,
characterized by extensive intratumoral heterogeneity. We aimed to systematically …
characterized by extensive intratumoral heterogeneity. We aimed to systematically …