Spatial transcriptomics reveals substantial heterogeneity in triple negative breast cancer with potential clinical implications

X Wang, D Venet, F Lifrange, D Larsimont, M Rediti… - 2024 - researchsquare.com
While triple negative breast cancer (TNBC) is known to be heterogeneous at the genomic
and transcriptomic levels, spatial information on tumor organization and cell composition is …

1711P Spatial transcriptomics reveals substantial heterogeneity in TNBC tumor and stroma compartments with potential clinical implications

X Wang, D Venet, F Lifrange, D Larsimont… - Annals of …, 2022 - annalsofoncology.org
Background Triple negative breast cancer (TNBC) is a heterogeneous disease
characterized by at least five molecular subtypes, namely basal like (BL) …

Spatial transcriptomic analysis of a diverse patient cohort reveals a conserved architecture in triple-negative breast cancer

R Bassiouni, MO Idowu, LD Gibbs, V Robila… - Cancer research, 2023 - AACR
Triple-negative breast cancer (TNBC) is an aggressive disease that disproportionately
affects African American (AA) women. Limited targeted therapeutic options exist for patients …

[PDF][PDF] Unraveling triple-negative breast cancer tumor microenvironment heterogeneity: towards an optimized treatment approach

Y Bareche, L Buisseret, T Gruosso… - JNCI: Journal of the …, 2020 - academic.oup.com
Background Recent efforts of gene expression profiling analyses recognized at least four
different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known …

50 Spatially resolved molecular investigation of triple negative breast cancer and its immune microenvironment

S Williams, C Uytingco, N Weisenfeld, N Delaney… - 2020 - jitc.bmj.com
Background Triple negative breast cancer (TNBC) accounts for 10–20% of all diagnosed
breast cancer cases in the US and is characterized by loss of HER2, estrogen receptors, and …

[HTML][HTML] Spatial and Compositional Biomarkers in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer

H Mi, R Varadhan, AM Cimino-Mathews, LA Emens… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited
treatment options, which warrants identification of novel therapeutic targets. Deciphering …

[HTML][HTML] Dissection of triple-negative breast cancer microenvironment and identification of potential therapeutic drugs using single-cell RNA sequencing analysis

W Cheng, W Mi, S Wang, X Wang, H Jiang… - Journal of …, 2024 - Elsevier
Breast cancer remains a leading cause of mortality in women worldwide. Triple-negative
breast cancer (TNBC) is a particularly aggressive subtype characterized by rapid …

Comprehensive spatial transcriptomic analysis of an integrated, diverse cohort reveals distinct molecular topographic patterns in triple negative breast cancer

R Bassiouni, M Idowu, LD Gibbs, PJ Grizzard… - Cancer Research, 2022 - AACR
Background: Triple negative breast cancer (TNBC) is an aggressive subtype of breast
cancer that disproportionately affects African-American and black (AAB) women, who have …

[PDF][PDF] A High-Dimensional Window into the Micro-Environment of Triple Negative Breast Cancer. Cancers 2021, 13, 316

I Nederlof, HM Horlings, C Curtis, M Kok - 2021 - info.submit4journal.com
Providing effective personalized immunotherapy for triple negative breast cancer (TNBC)
patients requires a detailed understanding of the composition of the tumor …

[HTML][HTML] Unraveling heterogeneity of tumor cells and microenvironment and its clinical implications for triple negative breast cancer

K Jiang, M Dong, C Li, J Sheng - Frontiers in Oncology, 2021 - frontiersin.org
Objective: Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer,
characterized by extensive intratumoral heterogeneity. We aimed to systematically …