Malaria is an infectious disease of global health importance with approximately half a million
global annual deaths. The sexual forms (gametocytes) are responsible for transmission of …

Background Transmission of malaria from man to mosquito depends on the presence of
gametocytes, the sexual stage of Plasmodium parasites in the infected host. Naturally …

Background Plasmodium falciparum gametocytes, specifically mature stages, are the only
stage in man transmissible to the mosquito vector responsible for malaria transmission. Anti …

Background The sexual stages (gametocytes) of Plasmodium falciparum do not directly
contribute to the pathology of malaria but are essential for transmission of the parasite from …

Malaria is a vector-borne disease that is still responsible for high human morbidity and
mortality. Of the five Plasmodium species that can cause malaria in humans, Plasmodium …

Despite extensive eradication campaigns malaria remains a major cause of morbidity and
mortality worldwide with an estimated 1-3 million deaths annually. There is widespread …

It is the mature gametocytes of Plasmodium that are solely responsible for parasite
transmission from the mammalian host to the mosquito. They are therefore a logical target …

Background Recent renewed emphasis on the eradication of malaria has highlighted the
need for more tools with which to achieve this ambitious goal. One high priority area is the …

Background Malaria elimination/eradication campaigns emphasize interruption of parasite
transmission as a priority strategy. Screening for new drugs and vaccines against …

Background: The sexual stages (gametocytes) of Plasmodium falciparum do not directly
contribute to the pathology of malaria but are essential for transmission of the parasite from …