Background The discovery of malaria transmission-blocking compounds is seen as key to
malaria elimination strategies and gametocyte-screening platforms are critical filters to …

Malaria remains a major cause of morbidity and mortality in the tropics, with Plasmodium
falciparum responsible for the majority of the disease burden and P. vivax being the …

Introduction Naturally acquired immune responses against antigens expressed on the
surface of mature gametocytes develop in individuals living in malaria-endemic areas …

During natural infection malaria parasites are injected into the bloodstream of a human host
by the bite of an infected female Anopheles mosquito. Both asexual and mature sexual …

Background Malaria remains a global health problem despite availability of effective tools.
For malaria elimination, drugs targeting sexual stages of Plasmodium falciparum need to be …

Background The innate immune response against various life cycle stages of the malaria
parasite plays an important role in protection against the disease and regulation of its …

The deadliest form of human malaria is primarily caused by the protozoan parasite
Plasmodium falciparum. These parasites establish pathogenicity in the human host with a …

Gametocytes (GCT), the sexual stage of malaria parasites, develop in five stages (IV).
Stages I-IV are mainly sequestered in the extravascular compartment of the bone marrow …

In response to a call for the global eradication of malaria, drug discovery has recently been
extended to identify compounds that prevent the onward transmission of the parasite, which …