Background A major requirement for malaria elimination is the development of transmission-
blocking interventions. In vitro transmission-blocking bioassays currently mostly rely on the …

The design of new antimalarial combinations to treat Plasmodium falciparum infections
requires drugs that, in addition to resolving disease symptoms caused by asexual blood …

Background: Malaria remains a global health problem despite availability of effective tools.
For malaria elimination, drugs targeting sexual stages of Plasmodium falciparum need to be …

Background Malaria, caused by Plasmodium parasites, remains a significant global health
challenge. Gametocytes are the sexual forms of the parasites which do not cause disease …

Gametocytes and sporogonic stages are responsible for the spread of disease and drug
resistance in the population. Sexual stage immunity affects the infectiousness of …

Natural immunity against malaria is acquired after repeated infections for an extended
period of time resulting in a state of immunological non-responsiveness against the malaria …

Causing an estimated 200 million clinical cases and more than 400000 deaths annually,
malaria represents one of the major threats to global public health (WHO, 2020). Malaria …

Sexual stages of Plasmodium falciparum play a key role in the transmission of malaria.
Studies on gametocytes are generally based on microscopical detection but more sensitive …

Malaria elimination will require interventions that prevent parasite transmission from the
human host to the mosquito. Experimentally, this is usually determined by the expensive and …

Subclinical infections that serve as reservoir populations to drive transmission remain a
hurdle to malaria control. Data on infection dynamics in a geographical area is required to …