The causes of cobalamin (B12, Cbl) deficiency are multifactorial. Whether nutritional due to
poor dietary intake, or functional due to impairments in absorption or intracellular processing …

Vitamin B12 (cobalamin, Cbl, B12) is an indispensable water-soluble micronutrient that
serves as a coenzyme for cytosolic methionine synthase (MS) and mitochondrial …

Abstract Vitamin B 12 (cobalamin, Cbl, B 12) is a water-soluble micronutrient synthesized
exclusively by a group of microorganisms. Human beings are unable to make B 12 and thus …

Nutritional deficiency and genetic errors that impair the transport, absorption, and utilization
of vitamin B 12 (B 12) lead to hematological and neurological manifestations. The cblC …

Abstract Cobalamin (Cbl, B 12) is an essential micronutrient required to fulfill the enzymatic
reactions of cytosolic methylcobalamin-dependent methionine synthase and mitochondrial …

The water-soluble vitamin, vitamin B 12, also known as cobalamin, plays a crucial role in
cellular metabolism, particularly in DNA synthesis, methylation, and mitochondrial …

Methylmalonic acidemia with homocystinuria, cobalamin deficiency type C
(cblC)(MMACHC) is the most common inborn error of cobalamin metabolism. Despite a …

Thiolatocobalamins are a class of cobalamins comprised of naturally occurring and synthetic
ligands. Glutathionylcobalamin (GSCbl) occurs naturally in mammalian cells, and also as an …

Three distinct classes of human mutations (cbl A, cbl B, and cbl C) cause defective synthesis
of cobalamin (Cbl; vitamin B12) coenzymes. Cultured fibroblasts from that unique class (cbl …

Background Vitamin B12 (cobalamin) is an essential cofactor in several metabolic pathways.
Intracellular conversion of cobalamin to its two coenzymes, adenosylcobalamin in …