Synthesis, biological evaluation, mechanism of action and quantitative structure–activity relationship studies of chalcones as antibacterial agents

PM Sivakumar, S Priya, M Doble - Chemical biology & drug …, 2009 - Wiley Online Library
Forty‐eight chalcone analogs were synthesized and their in vitro antibacterial activity
against Staphylococcus aureus NCIM 5021, Bacillus subtilis NCIM 2718, Phaseolus vulgaris …

Structure–activity relationship of antibacterial chalcones

HP Ávila, EFA Smânia, F Delle Monache… - Bioorganic & medicinal …, 2008 - Elsevier
The antibacterial activity of 31 chalcones was tested against bacterial strains, Bacillus
cereus ATCC 11778, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC …

Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics

TD Tran, TTN Nguyen, TH Do, TNP Huynh, CD Tran… - Molecules, 2012 - mdpi.com
A series of simple heterocyclic chalcone analogues have been synthesized by Claisen
Schmidt condensation reactions between substituted benzaldehydes and heteroaryl methyl …

In vitro antimicrobial and antimycobacterial activity of some chalcones and their derivatives

D Patel, P Kumari, NB Patel - Medicinal Chemistry Research, 2013 - Springer
In this study, novel series of chalcone derivatives, namely, 4-[4-(3-phenyl-acryloyl)-
phenylamino]-chromen-2-one (5a–k) have been synthesized from the intermediate 4-(4 …

Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics

TD Tran, TH Do, NC Tran, TD Ngo, CD Tran… - Bioorganic & medicinal …, 2012 - Elsevier
A total of 30 chalcone analogues was synthesized via a base catalyzed Claisen Schmidt
condensation and screened for their in vitro antibacterial activity against Methicillin-sensitive …

Synthesis and biological activity of new chalcone scaffolds as prospective antimicrobial agents

S Narwal, S Kumar, PK Verma - Research on Chemical Intermediates, 2021 - Springer
Chalcones are open-chain flavonoids which contains two aromatic rings are joined by 3-
carbons α-, β-unsaturated carbonyl chain. The, β-unsaturated ketonic group which is liable …

Recent developments of chalcones as potential antibacterial agents in medicinal chemistry

W Dan, J Dai - European journal of medicinal chemistry, 2020 - Elsevier
Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted

D Batovska, S Parushev, B Stamboliyska… - European journal of …, 2009 - Elsevier
A large series of chalcones were synthesized and studied against Staphylococcus aureus
and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4′-chloro …

Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties

ZY Wei, KQ Chi, ZK Yu, HY Liu, LP Sun… - Bioorganic & medicinal …, 2016 - Elsevier
Three novel series of chalcone derivatives containing an aminoguanidine or acylhydrazone
moiety were designed, synthesized and evaluated in terms of their antibacterial, antifungal …

Synthesis, antimicrobial, and computational evaluation of novel isobutylchalcones as antimicrobial agents

AB Shaik, RP Yejella, S Shaik - International journal of …, 2017 - Wiley Online Library
A series of 25 new chalcones were synthesized by Claisen‐Schmidt condensation, well
characterized by spectroscopic data, and evaluated for their antibacterial and antifungal …