Sustained release of valproic acid loaded on chitosan nanoparticles within hybrid of alginate/chitosan hydrogel with/without stem cells in regeneration of spinal cord …

MA Jafarimanesh, J Ai, S Shojaei, HA Khonakdar… - Progress in …, 2023 - Springer
Hydrogels have been increasingly applied in tissue regeneration and drug delivery systems
(DDS). In this study, the capacity of valproic acid (Val) encapsulated within hybrid of alginate …

Berberine loaded chitosan nanoparticles encapsulated in polysaccharide-based hydrogel for the repair of spinal cord

S Mahya, J Ai, S Shojae, HA Khonakdar… - International Journal of …, 2021 - Elsevier
The potential of berberine loaded in chitosan nanoparticles (BerNChs) within a hybrid of
alginate (Alg) and chitosan (Ch) hydrogel was investigated for the substrate which is known …

Peripheral nerve regeneration in rats by chitosan/alginate hydrogel composited with Berberine and Naringin nanoparticles: in vitro and in vivo study

MH Ebrahimi, H Samadian, ST Davani… - Journal of Molecular …, 2020 - Elsevier
In the current study, we prepared chitosan (Cs)/Alginate (Alg) hydrogel containing Berberine
(Ber)-loaded Cs nanoparticles (NPs) and Naringin (Nar)-loaded Cs NPs as the promising …

Spinal cord injury repair by implantation of structured hyaluronic acid scaffold with PLGA microspheres in the rat

Y Wen, S Yu, Y Wu, R Ju, H Wang, Y Liu… - Cell and Tissue …, 2016 - Springer
In order to create an optimal microenvironment for neural regeneration in the lesion area
after spinal cord injury (SCI), we fabricated a novel scaffold composed of a hyaluronic acid …

Chitosan/gelatin hydrogel and endometrial stem cells with subsequent atorvastatin injection impact in regenerating spinal cord tissue

ME Astaneh, A Goodarzi, M Khanmohammadi… - Journal of Drug Delivery …, 2020 - Elsevier
Central nervous system trauma can cause loss of functional sensory neurons and motor
functions that results in death of neuronal cells and axon degeneration. For this purpose …

[HTML][HTML] Efficacy of chitosan and sodium alginate scaffolds for repair of spinal cord injury in rats

Z Yao, F Chen, H Cui, T Lin, N Guo… - Neural regeneration …, 2018 - journals.lww.com
Spinal cord injury results in the loss of motor and sensory pathways and spontaneous
regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium …

Diacerein loaded poly (styrene sulfonate) and carbon nanotubes injectable hydrogel: an effective therapy for spinal cord injury regeneration

S Xing, M Yan, Y Yang, Y Wang, X Hu, B Ma… - Journal of Cluster …, 2023 - Springer
Good structural features with good conduction to transfer the electrical signal in the spinal
cord are perilous in nerve soft tissue repairing materials preparation. In this research work …

[HTML][HTML] Alginate-based hydrogel containing taurine-loaded chitosan nanoparticles in biomedical application

A Goodarzi, M Khanmohammadi… - Archives of …, 2019 - brieflands.com
: The hydrogel efficacy of taurine-loaded chitosan nanoparticle/alginate hydrogel was
investigated for controlled release of the taurine substrate, which is known as an …

Combination of hyaluronic acid hydrogel scaffold and PLGA microspheres for supporting survival of neural stem cells

Y Wang, YT Wei, ZH Zu, RK Ju, MY Guo… - Pharmaceutical …, 2011 - Springer
Purpose To develop a biomaterial composite for promoting proliferation and migration of
neural stem cells (NSCs), as well as angiogenesis on the materials, to rescue central …

[HTML][HTML] Chitosan-based hydrogel to support the paracrine activity of mesenchymal stem cells in spinal cord injury treatment

M Boido, M Ghibaudi, P Gentile, E Favaro, R Fusaro… - Scientific reports, 2019 - nature.com
Advanced therapies which combine cells with biomaterial-based carriers are recognized as
an emerging and powerful method to treat challenging diseases, such as spinal cord injury …