Hypoxia-inducible factors (HIFs) play key roles in the cellular response to hypoxia. It is
widely accepted that whereas HIF-1 and HIF-2 function as transcriptional activators, HIF-3 …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix transcription
factor that regulates hypoxia-inducible genes including the human erythropoietin (EPO) …

ABSTRACT A great many aspects of the anatomy and physiology of large animals are
constrained by the need to match oxygen supply to cellular metabolism and appear likely to …

We have previously shown marked induction of the stress-inducible gene heme oxygenase-
1 (HO-1) in vivo and in vitro after hyperoxia. In RAW 264.7 cells, HO-1 induction is …

Heme oxygenase 1 (HO-1), a rate-limiting enzyme in heme catabolism, has been reported to
be induced by hypoxia. Unexpectedly, here we show that expression of HO-1 mRNA is …

The heterodimeric hypoxia-inducible transcription factor HIF-1 is involved in the oxygen-
regulated transcription of several genes including erythropoietin. Cloning and sequencing of …

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that mediates cellular and
systemic homeostatic responses to reduced O2 availability in mammals, including …

Cellular responses to oxygen are increasingly recognized as critical in normal development
and physiology, and are implicated in pathological processes. Many of these responses are …

Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote
or repress the transcription of a broad range of genes that are involved in maintaining …

The transcription factor hypoxia inducible factor α‐subunit (HIFα) is pivotal in the cellular
response to the stress of hypoxia. Post‐translational modification of HIFα by hydroxylase …