The role of the hypoxia-inducible factor (HIF) subunits 1α and 2α in response to hypoxia is
well established in lung epithelial cells, whereas little is known about HIF-3α with respect to …

Structural and functional analysis of hypoxia-inducible factor 1. Hypoxia-inducible factor 1
(HIF-1) is a basic helix-loop-helix protein that activates transcription of hypoxia-inducible …

Transcription of the human erythropoietin (EPO) gene is activated in Hep3B cells exposed to
hypoxia. Hypoxia-inducible factor 1 (HIF-1) is a nuclear factor whose DNA binding activity is …

Hypoxia-inducible factor 1 (HIF-1) is an oxygen-regulated transcriptional activator that plays
essential roles in mammalian development, physiology and disease pathogenesis. The HIF …

Recent studies of tissue culture cells have defined a widespread system of oxygen-
regulated gene expression based on the activation of a heterodimeric transcription factor …

Hypoxia-inducible factor 1 (HIF-1) is a basic-helix-loop-helix transcription factor that plays
essential roles in mammalian development and physiology. HIF-1 is a heterodimer …

Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor consisting of HIF-1α
and HIF-1β subunits, controls the expression of a large number of genes involved in the …

Hypoxia, or lowered physiological oxygenation, is a component of many diseases. The
response to decreased oxygen tensions is also an essential aspect of normal development …

The hypoxia-inducible transcription factors (HIFs) play a central role in the response of cells
to hypoxia. HIFs are αβ dimers, the human α subunit having three isoforms. HIF-3α is unique …

Hypoxia-inducible factor-1 (HIF-1) has been shown to mediate the transcriptional activation
of its target genes in response to oxygen concentration, most likely via a pathway involving a …