Hypoxia-inducible factor-1, HIF1, transcriptionally activates over 200 genes vital for cell
homeostasis and angiogenesis. We developed a computational model to gain a detailed …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a
number of adaptive responses to low oxygen tension. They are composed of α-and β …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric basic helix-loop-helix (bHLH)-PAS
DNA-binding protein tightly regulated by cellular oxygen tension. Cellular redox states are …

Oxygen-dependent proteolysis is the primary means of regulating the hypoxia-inducible
factor (HIF) family of transcription factors. The alpha-subunit of HIF factor 1 (HIF-1) contains …

Cells experiencing lowered O2 levels (hypoxia) undergo a variety of biological responses in
order to adapt to these unfavorable conditions. The master switch, orchestrating the cellular …

The hypoxia-inducible factor (HIF) activates the expression of genes that contain a hypoxia
response element. The α-subunits of the HIF transcription factors are degraded by …

Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that plays a crucial role
in mediating cellular responses to oxygen. Oxygen availability influences multiple steps in …

The hypoxia-inducible factor-1 (HIF-1) is a key regulator of oxygen homeostasis in the cell.
We have previously shown that HIF-1α and the transcriptional coactivator CBP colocalize in …

The hypoxia-inducible factor (HIF) family has three distinct members in most vertebrates. All
three HIFs consist of a unique and oxygen-labile α-subunit and a common and stable β …

The hypoxia-inducible factor (HIF) system orchestrates cellular responses to hypoxia in
animals. HIF is an α/β-heterodimeric transcription factor that regulates the expression of …