Transcription of hypoxia-inducible genes is regulated by hypoxia response elements (HREs)
located in either the promoter or enhancer regions. Analysis of these elements reveals the …

Hypoxia-inducible factor-1 (HIF-1) controls the expression of a number of genes such as
vascular endothelial growth factor and erythropoietin in low oxygen conditions. However, the …

All organisms can sense O2 concentration and respond to hypoxia with adaptive changes in
gene expression. The large body size of mammals necessitates the development of multiple …

Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator that functions as a master
regulator of cellular and systemic oxygen homeostasis. It consists of two constitutively …

Mammalian cells are able to sense oxygen and regulate a number of genes in response to
hypoxia. The transcription factor Hypoxia Inducible Factor-1 (HIF-1) was identified as an …

Hypoxia-inducible factor (HIF)-1 is a basic helix-loop-helix transcription factor that
transactivates genes encoding proteins that participate in homeostatic responses to hypoxia …

ABSTRACT A universal response to changes in cellular oxygen tension is governed by a
family of heterodimeric transcription factors called hypoxia‐inducible factor (HIF). Tumor …

Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …

The cellular response to hypoxia includes the hypoxia-inducible factor-1 (HIF-1)-induced
transcription of genes involved in diverse processes such as glycolysis and angiogenesis …

Hypoxic induction of erythropoietin (Epo) and other oxygen-dependent genes is mediated
by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transactivator consisting of an α …