Are inhaled corticosteroids associated with an increased risk of fracture in children?

TP van Staa, N Bishop, HGM Leufkens… - Osteoporosis …, 2004 - Springer
Inhaled corticosteroids are widely used in the long-term management of asthma in children.
Data on the relationship between inhaled corticosteroid therapy and osteoporotic fracture …

Association between inhaled corticosteroid use and bone fracture in children with asthma

N Gray, A Howard, J Zhu, LY Feldman, T To - JAMA pediatrics, 2018 - jamanetwork.com
Importance Daily use of inhaled corticosteroids is a widely recommended treatment for mild
persistent asthma in children. There is concern that, similar to systemic corticosteroids …

Inhaled corticosteroids and the risk of fractures in children and adolescents

RG Schlienger, SS Jick, CR Meier - Pediatrics, 2004 - publications.aap.org
Objective. To determine whether children or adolescents who are exposed to inhaled
corticosteroids (ie, beclomethasone, budesonide, fluticasone) are at a higher risk of having …

Effect of long-term corticosteroid use on bone mineral density in children: a prospective longitudinal assessment in the childhood Asthma Management Program …

HW Kelly, ML Van Natta, RA Covar, J Tonascia… - …, 2008 - publications.aap.org
OBJECTIVE. Systemic corticosteroids are known to induce osteoporosis and increase the
risk for fractures in adults and children. Inhaled corticosteroids have been shown to increase …

Effects of inhaled corticosteroids on bone

KJ Mortimer, TW Harrison, AE Tattersfield - Annals of Allergy, Asthma & …, 2005 - Elsevier
OBJECTIVE: To discuss the effects of inhaled corticosteroids on bone and their potential
public health implications. DATA SOURCES: The MEDLINE and EMBASE databases were …

Inhaled and nasal corticosteroid use and the risk of fracture

S Suissa, M Baltzan, R Kremer… - American journal of …, 2004 - atsjournals.org
Studies of the risk of fracture associated with inhaled corticosteroids are inconclusive and
are limited to short-term effects. We assessed whether long-term use increases this risk. We …

The skeletal effects of inhaled glucocorticoids

SA Sutter, EM Stein - Current osteoporosis reports, 2016 - Springer
The skeletal effects of inhaled glucocorticoids are poorly understood. Children with asthma
treated with inhaled glucocorticoids have lower growth velocity, bone density, and adult …

Use of inhaled corticosteroids and risk of fractures

TP Van Staa, HGM Leufkens… - Journal of Bone and …, 2001 - academic.oup.com
Abstract Treatment with systemic corticosteroids is known to increase the risk of fractures but
little is known of the fracture risks associated with inhaled corticosteroids. A retrospective …

Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma: systematic review and meta-analysis

YK Loke, D Gilbert, M Thavarajah, P Blanco… - BMJ open, 2015 - bmjopen.bmj.com
Objectives We aimed to assess the association between long-term use of inhaled
corticosteroids (ICS) and bone adverse effects in patients with asthma. Design Systematic …

Inhaled corticosteroids and hip fracture: a population-based case–control study

RB Hubbard, CJP Smith, L Smeeth… - American journal of …, 2002 - atsjournals.org
There is accumulating evidence that the use of inhaled corticosteroids is associated with a
dose-related reduction in bone mineral density. Whether this translates to an increase in …