Low-dose mifepristone inhibits endometrial proliferation and up-regulates androgen receptor
Mifepristone in daily low doses has contraceptive potential by inhibiting ovulation. Follicular
development is maintained, and although the endometrium is exposed to unopposed …
development is maintained, and although the endometrium is exposed to unopposed …
[HTML][HTML] Effect of mifepristone on proliferation and apoptosis of Ishikawa endometrial adenocarcinoma cells
A Li, JC Felix, P Minoo, CA Amezcua, JK Jain - Fertility and sterility, 2005 - Elsevier
OBJECTIVE: To determine the mechanism by which mifepristone improves breakthrough
bleeding, the effects of mifepristone on proliferation and apoptosis of Ishikawa endometrial …
bleeding, the effects of mifepristone on proliferation and apoptosis of Ishikawa endometrial …
[HTML][HTML] A hypothetical model suggesting some possible ways that the progesterone receptor may be involved in cancer proliferation
JH Check, DL Check - International Journal of Molecular Sciences, 2021 - mdpi.com
Cancer and the fetal-placental semi-allograft share certain characteristics, eg, rapid
proliferation, the capacity to invade normal tissue, and, related to the presence of antigens …
proliferation, the capacity to invade normal tissue, and, related to the presence of antigens …
Pharmacological properties of mifepristone: toxicology and safety in animal and human studies
R Sitruk-Ware, IM Spitz - Contraception, 2003 - Elsevier
Roussel Uclaf in partnership with the INSERM unit of Prof. EE Baulieu first discovered
mifepristone (RU486) as part of a large research program on steroidal compounds with …
mifepristone (RU486) as part of a large research program on steroidal compounds with …
Mifepristone treatment improves length and quality of survival of mice with spontaneous lung cancer
JH Check, L Sansoucie, J Chern, E Dix - Anticancer research, 2010 - ar.iiarjournals.org
Background: There are data showing that human leukemia cell lines have mRNA for an
immunomodulatory protein found in normal pregnancy that is stimulated by progesterone …
immunomodulatory protein found in normal pregnancy that is stimulated by progesterone …
A phase II evaluation of mifepristone in the treatment of recurrent or persistent epithelial ovarian, fallopian or primary peritoneal cancer: a gynecologic oncology group …
OBJECTIVE: To evaluate the effectiveness and toxicity of mifepristone in patients with
ovarian, peritoneal and fallopian tube cancers. METHODS: Patients with confirmed epithelial …
ovarian, peritoneal and fallopian tube cancers. METHODS: Patients with confirmed epithelial …
[HTML][HTML] Antiprogestins in gynecological diseases
AA Goyeneche, CM Telleria - Reproduction (Cambridge, England), 2015 - ncbi.nlm.nih.gov
Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …
[HTML][HTML] Mifepristone prevents repopulation of ovarian cancer cells escaping cisplatin-paclitaxel therapy
CD Gamarra-Luques, AA Goyeneche, MB Hapon… - BMC cancer, 2012 - Springer
Background Advanced ovarian cancer is treated with cytoreductive surgery and combination
platinum-and taxane-based chemotherapy. Although most patients have acute clinical …
platinum-and taxane-based chemotherapy. Although most patients have acute clinical …
Pre-clinical and clinical treatment of breast cancer with antiprogestins
JGM Klijn, B Setyono-Han, HJ Sander… - Human …, 1994 - academic.oup.com
Antiprogestins form a new potential treatment modality for breast cancer and their mode of
action has been assessed in vitro on several breast cancer cell lines, in vivo in rats with …
action has been assessed in vitro on several breast cancer cell lines, in vivo in rats with …